摘要
目的:通过检测鼻咽癌患者治疗前血清中TGF-β1的浓度,探讨其与鼻咽癌患者临床特征及预后的关系。方法:采用酶联免疫吸附(ELISA)实验方法,检测初治156例鼻咽癌患者治疗前血清中的TGF-β1表达水平,分析血清中TGF-β1浓度对鼻咽癌预后的影响。结果:156例鼻咽癌患者治疗前血清TGF-β1的平均浓度明显高于健康对照组〔(60.24±28.33)ng/mLvs(30.14±14.14)ng/mL〕。进而以52.11 ng/mL为节点,将156例鼻咽癌患者分成TGF-β1高、低浓度组,两组间3年无转移生存率差异有统计学意义,P=0.000。Cox多因素回归结果显示,鼻咽癌患者治疗前血清中高浓度TGF-β1是总生存和无转移生存的不良预后因素,P均<0.001。结论:鼻咽癌患者治疗前血清中TGF-β1浓度可能成为预测鼻咽癌治疗后远处转移的分子指标之一。
OBJECTIVE： To explore the correlation of transforming growth factor-β1 and nasopharyngeal carcinoma by testing the levels of plasma TGF-α1. METHODS： A total of 156 untreated NPC patients were enrolled in this study. The levels of plasm TGF-β1 were quantified using ELISA. The correlation of TGF-β1 and nasopharyngeal carcinoma was analyzed. RESULTS： The plasma concentration of TGF-β1 in untreated NPC patients was significant higher than that in controls [（60.24 ± 28.33） ng/mL vs （30. 14±14. 14） ng/mL]. By the median plasma concentration 52.11 ng/mL of TGF-β1, the untreated NPC patients was divided into high concentration group and low concentration group. The significances were detected in 3-year distant metastasis -free survival rate （P=0. 000）. Multivariate analysis revealed that plasma concentration of TGF-β1 may predict the low overall survival rate and distant metastasis after treatment（P〈0. 001）. CONCLUSION： High level of plasma TGF-β1 before treatment may predict distant metastasis of NPC patients after treatment.
出处
《中华肿瘤防治杂志》
CAS
2011年第1期22-25,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
中山大学肿瘤防治中心出国留学人员科研启动基金(303041217001)
广东省医学科学技术研究基金(A2010188)
关键词
鼻咽肿瘤
信号传导
转化生长因子Β
预后
nasopharyngeal neoplasms
signal transduction
transforming growth factor beta
Prognosis
