摘要
２（４异丁基苯基）丙酸（俗称布洛芬）是一种重要的解热镇痛消炎药物［１］，经典的生产路线是由异丁基苯出发，经弗克反应、达村缩合，最后经氧化制得［２］；其合成步骤多，成品精制难，生产成本高．美国于１９９２年通过１（４异丁基苯基）乙醇（ＩＢＰＥ）羰...
In this paper, the effects of NaOH amount, reaction temperature, catalyst concentration and hydrogen pressure on the hydrogenation of pisobutyl acetophenone (IBAP) over 5% Pd/C are investigated in detail. The optimum reaction conditions are as follows: p (H2) =09 MPa, T=303 K, m (5%Pd/C) =04 g, and m (NaOH) =008 g. The conversion of IBAP and the yield of 1(4isobutylphenyl)ethanol (IBPE) are 995% and 958%, respectively. The hydrogenation reaction follows the first order kinetics with respect to IBAP concentration, catalyst concentration and hydrogen pressure, respectively. The activation energy for this reaction is ca 422 kJ/mol.
出处
《催化学报》
SCIE
CAS
CSCD
北大核心
1999年第4期471-474,共4页
基金
辽宁省国际合作基金
关键词
异丁基苯乙酮
异丁基苯基乙醇
加氢
钯
布洛芬
isobutyl acetophenone, isobutyl phenylethanol, hydrogenation, palladium, activated carbon
