摘要
目的:了解踝肱指数(ABI)与糖尿病足发生率的关系,并探讨其相关危险因素,以便早期采取有效措施预防糖尿病足的发生。方法:438例确诊为2型糖尿病的住院患者,分为非糖尿病足组(NDF)391例及糖尿病足组(DF)47例,所有患者均进行ABI及糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)等生化资料的检测,比较两组临床生化资料及不同ABI组糖尿病足患病率的差异,并进行糖尿病足相关危险因素的logistic回归分析。结果:1两组间比较,年龄、性别、病程、HbA1C及LDL、超敏CRP、高血压及吸烟史、糖尿病肾病及视网膜病变差异显著;2ABI与糖尿病足患病率呈类似"U"型分布的关系,不同ABI组间患病率有显著性差异;3logistic回归显示:2型糖尿病年龄、病程、HbA1C、ABI及糖尿病肾病是糖尿病足病变发生的危险因素。结论:ABI与DF的发生存在明显的相关性,ABI降低或异常升高可早期预测糖尿病足的发生,对有ABI异常的高危糖尿病患者积极采取有效的干预措施意义重大。
Objective：To explore the dependablity between ankle brachial index（ABI） and incidence rate of diabetic foot（DF） and analyze its correlated risk factor,in order to take effectieve measures early to prevent the occurrence of DF.Methods：438 cases of type 2 diabetes were divided into the non-diabetic foot group（NDF,391 cases） and the diabetic foot group（DF,47 cases）,all patients were detected ABI,glycosylated hemoglobin（HbA1c）,cholesterol total（TC）,triglyceride（TG） and so on,compared with the difference of biochemistry index between the two groups and the disparity of morbidity rate in diabetic foot between different ABI,analyzed the correlated risk factor in DF.Results：①Age,sex,the course of disease,HbA1C,low-density lipoprotein,S-CRP,history of hypertension and smoking,complicating diabetic nephropathy and retinopathy had significant difference between two groups comparison;②It was similar U-type distribution between ABI and incidence rate of DF and there was significant difference in different ABI groups of DF＇s prevalence;③Logistic regression analysis revealed that the age,the course of disease,HbA1C,ABI,and complicating diabetic nephropathy of type 2 diabetes were risk factors of DF.Conclusions：There is relationship between ABI and occurrence of DF,reduce and abnormal rise of ABI can predict the morbidity of DF early,so it is significant to take positive and effective intervention in the group of diabetic with abnormal ABI.
出处
《陕西医学杂志》
CAS
2011年第3期298-301,共4页
Shaanxi Medical Journal
