摘要
目的探讨精神分裂症患者的血清肌酸激酶(CK)活性与攻击行为的关系。方法对47例精神分裂症患者给予攻击行为量表(OAS)评定并分组,于入院及治疗第2、4、8周分别抽取患者空腹静脉血样,测定其血清CK活性。结果入院时攻击组与治疗初期(2周)攻击组CK活性与非攻击组间差异有统计学意义(P<0.01),治疗中、后期(第4、8周)与非攻击组CK活性比较差异无统计学意义(P>0.05)。结论 CK活性增高可能与伴攻击行为精神分裂症患者的病情程度及治疗效果有关,为精神分裂症的生物学参考指标改变之一。
Objective To explore the relationship between the activity of creatine kinase （CK） in schizophrenia patientsr serum and patients~ aggressive behavior. Methods 47 schizophrenia patients were divided into different groups according to their overt aggression scale （OAS） scores. Their serum CK activity was detected when they were admitted to hospital and 2,4,8 weeks after that,respectively. Results Compared with the control group,serum CK activity of patients with aggressive behavior was signifi-cantly different （P〈0.01） ,and concordant with the control group in the medium and later stage of treatment. Conclusion The increase of CK activity might be associated with the severity of schizophrenia with aggressive behavior and related with the treatment for schizophrenia. It could be one of the biological reference markers of schizophrenia.
出处
《国际检验医学杂志》
CAS
2011年第3期338-339,共2页
International Journal of Laboratory Medicine
关键词
精神分裂症
肌酸激酶
研究
schizophrenia
creatine klnase
research
