摘要
目的:探讨聚丙烯酰胺水凝胶(PAAG)注射隆乳后并发症、MRI表现、组织病理学变化与注入时间的关系。方法:选取PAAG隆乳术后要求取出假体的35例个体(70只乳房假体)为研究对象,注入时间1周～6年,按注入时间分为2年以内组(n=7),2～4年组(n=11),4～6年组(n=17)3组。以术前乳房触诊结果记录各组临床并发症例数。对35例个体的MRI结果进行分级,记录各组MRI分级例数。将临床并发症、MRI表现与组织学变化进行对照分析,并将以上三者分别与注入时间进行相关性分析,所有数据采用卡方线性趋势检验,P<0.05认为差异有统计学意义。结果:出现临床并发症19例,其中2年以内组2例,2～4年组4例,4～6年组13例;MRI表现异常26例,2年以内组2例,2～4年组9例,4～6年组15例;组织病理学异常16例,2年以内组1例,镜下见注射物蓝紫色,周围可见多核巨细胞,少量成纤维细胞和炎性细胞;2～4年组3例,镜下见淋巴细胞和多核细胞轻度增生;4～6年组12例,镜下见淋巴细胞和成纤维细胞增生明显,异物巨细胞增生弱。经统计学分析,隆乳后临床并发症、MRI异常表现、组织病理学变化的出现与注入时间均存在相关性(P<0.05)。结论:PAAG注入时间越长,临床并发症、MRI异常表现、组织病理学变化越明显;MRI对并发症的诊断和远期组织病理学评估有较大价值。
Objective：To explore the correlation between clinical symptoms,MRI findings,histopathology change and the length of time after injection of polyacrylamide hydrogel（PAAG） for breast augmentation.Methods：There were 35 individuals（70 breast prosthesis） included in our study who required to remove the prosthesis after breast augmentation 1 week to 6 years.According to injection time,they were divided into the following 3 groups： less than 2 years（n=7）,2~4 years group（n=11）,and more than 4 years group（n=17）.The number of cases with clinical complications in each group on the basis of the results of preoperative palpation of the breast was recorded.MRI results of 35 individuals were classified and graded,number of patients in each group was recorded.The clinical complications,MRI findings and histopathology change were comparatively analyzed;the relation between three of them and the injection time was determined,respectively.Statistical analyses were performed using chi-square linear tendency test,P0.05 considered to be significant difference.Results：19 patients had clinical complications,from which 2 cases occurred in 2 years.4 cases occurred in 2~4 years.The others occurred in 4 years later.26 cases showed abnormal manifestations in MRI,2 in 2 years,9 in 2~4 years and 15 after 4 years.16 patients could be seen with abnormal pathology.In a patient who was injected less than 2 years ago,there were multinucleated giant cells around the amethyst injection and a few fibroblasts and inflammatory cells.3 patients in 2~4 years could be seen with slightly hyperplasia of lymphocytes and multinucleated cells.There were 12 patients who could be seen with obvious hyperplasia of lymphocytes and fibroblasts after 4 years.Statistical analyses showed that clinical symptoms,MRI findings and histology change were correlated to the injection time（P0.05）.Conclusion：The longer the time after injection,the more obvious the clinical complications,MRI findings and histopathology change.MRI has great diagnostic value in the detection and management of complications and evaluation of long-term histopathology change after PAAG injection.
出处
《放射学实践》
北大核心
2011年第2期194-198,共5页
Radiologic Practice
关键词
磁共振成像
病理学
Magnetic resonance imaging
Pathology
