摘要
目的探讨老年原发性高血压患者血压变异性(BPV)与靶器官损害的关系。方法①收集符合纳入标准的老年人群资料,分为高血压组(n=146)和正常对照组(n=51),比较两组24 h收缩压/舒张压变异性(24 hSBPV/DBPV)、24 h平均收缩压/舒张压(24 h SBP/DBP)、日间收缩压/舒张压变异性(d SBPV/DBPV)及夜间收缩压/舒张压变异性(n SBPV/DBPV);②根据24 h SBPV第50百分位数(P50)将高血压组分为高BPV组和低BPV组,比较高BPV组、低BPV组、正常对照组的血脂、颈总动脉内-中膜厚度(IMT)、左室质量指数(LVMI)、24 h尿微量白蛋白(MA)、合并心血管疾病等指标;③再分别以各危险因素为自变量,IMT、LVMI、MA为因变量进行多因素分析。结果①高血压组24 h SBPV、d SBPV高于对照组(P<0.001,P<0.05)。②高BPV组冠心病、DM、IMT、LVMI、MA、粥样斑块发生率高于低BPV组(P<0.05或P<0.01)。③多因素分析显示,24 h SBPV与IMT、LVMI、MA均有相关关系。结论老年高血压患者BPV增高,BPV是高血压靶器官损伤的重要预测指标。
Objective To investigate the relationship between blood pressure variability（BPV）and target-organ damage in elderly patients with hypertension.Methods A total of 197 elderly patients were included in the study.The participants were divided into two groups： those with hypertension（n=146） and those without hypertension（Control,n=51）.The 24 h systolic and diastolic blood pressure variability（24 h SBPV/DBPV）,24 h average systolic and diastolic blood pressure（24 h SBP/DBP）,day time systolic and diastolic blood pressure variability（d SBPV/DBPV）,and night time systolic and diastolic blood pressure variability（n SBPV/DBPV）were measured.The hypertensive group was further divided into low and high variability groups according to the 50th percentile of 24 h SBPV.The carotid artery intima-media thickness（IMT）,left ventricular mass index（LVMI）,24 h microalbuminuria （MA） and basic clinical and laboratory parameters were compared among the groups.The correlations between blood pressure variability and IMT,LVMI,and MA were analyzed with multivariable regression analyses.Results The patients with essential hypertension had significantly higher 24 h SBPV（P〈0.001） and d SBPV（P〈0.05） than those without hypertension.The patients with higher blood pressure variability had greater incidence of plaque and cardiovascular disorder,as well as IMT,LVMI and MA（P〈0.001）.The prevalence of diabetes mellitus（DM） differed significantly among the three groups of participants（P〈0.05）.The multivariable regression analysis showed that 24 h SBPV was independently correlated with IMT,LVMI and MA.Conclusion Elderly patients with hypertension have high BPV,which is an important independent predictor of target-organ damage.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2011年第2期252-255,共4页
Journal of Sichuan University(Medical Sciences)
关键词
原发性高血压
老年患者
血压变异性
靶器官损害
Essential hypertension Elderly patients Blood pressure variability Target-organ damage
