摘要
目的探讨乳腺梭形细胞癌的病理组织学形态特征、诊断与鉴别诊断。方法复习2例乳腺梭形细胞癌的临床资料,观察其组织病理学表现,并进行免疫组化染色,同时回顾总结相关文献资料。结果 2例均为女性,年龄分别为46岁和60岁。肿瘤直径分别为2 cm和2.8 cm。2例肿瘤均由梭形细胞组成,其间可见少量上皮样细胞,其中例1细胞较丰富,细胞排列成束状;例2由温和的梭形细胞组成,间质有明显的玻璃样变,组织形态类似于纤维瘤病。肿瘤组织中的梭形细胞及上皮样细胞CK、CK5/6、34βE12和p63(+)。例1术后5个月复发。结论乳腺梭形细胞癌是乳腺的一种化生性癌,易误诊,诊断时需与纤维瘤病、叶状肿瘤和乳腺肉瘤等鉴别。梭形细胞癌预后不良,常常发生局部复发和远处转移,但低级别纤维瘤病样梭形细胞癌预后较好。
Objective To discuss the histopathological characteristics,diagnosis and differential diagnosis of spindle cell carcinoma of the breast.Methods Two cases of spindle cell carcinoma of the breast and relative literatures were reviewed.Both tumors were investigated by histopathology,and immunohistochemical staining.Results Two cases occurred in women,and their age was 46 and 60 years,respectively.Tumor size ranged from 2.0-2.8 cm.The both tumors were composed predominantly of spindle cells with a cluster of epithelioid cells.The lesion of one case showed the cellular fascicular spindle cell architecture with atypia,but the other consisted of bland spindle cells with densely hyaline collagenous tissue,mimicking fibromatosis.Both spindle cells and epithelioid cells expressed CK,CK5 /6,34βE12 and p63.One case recurred 5 months after surgery.Conclusions Spindle cell carcinoma is a unique metaplastic carcinoma in the breast and easy to be misdiagnosed.It should be distinguished from fibromatosis,phylloides tumor and fibrosarcoma.The overall prognosis of spindle cell carcinoma of breast is poor with high frequency of local recurrence and distant metastasis,except fibromatosis-like spindle cell carcinoma.
出处
《诊断病理学杂志》
CSCD
2011年第1期12-15,共4页
Chinese Journal of Diagnostic Pathology
关键词
乳腺
梭形细胞癌
化生性癌
Breast
Spindle cell carcinoma
Metaplastic carcinoma
