期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

吡咯并[2,3-d]嘧啶衍生物的合成方法研究进展 被引量：2

Research Progress in the Synthesis Method of Pyrrolo [2,3-d] Pyrimidine Derivatives
在线阅读 下载PDF
导出
摘要 归纳总结了2,4-二氨基吡咯并[2,3-d]嘧啶和2-氨基-4-氧代吡咯并[2,3-d]嘧啶的主要合成方法,并对各方法的优缺点进行了简要评述。参考文献30篇。 The main synthesis methods of 2,4-diamino-pyrrolopyrimidine and 2-amino-4-oxo-pyrrolopyrimidine were summarized with 30 references.The advantages and disadvantages were were summed briefly reviewed on various way.
作者 袁京莉 史博颖 鲁丰 曹胜利
机构地区 首都师范大学化学系
出处 《合成化学》 CAS CSCD 北大核心 2011年第2期149-156,共8页 Chinese Journal of Synthetic Chemistry
基金 国家自然科学基金资助项目(20972099)
关键词 2 4-二氨基吡咯并[2 3-d]嘧啶 2-氨基-4-氧代吡咯并[2 3-d]嘧啶 合成 综述 2 4-diamino-pyrrolopyrimidine 2-amino-4-oxo-pyrrolopyrimidine synthesis review
分类号 O626.41 [理学—有机化学] O616.13 [理学—无机化学]
  • 相关文献

参考文献33

  • 1Itoh F, Russello O, Akimoto H, et al. Novel pyrrolo [ 2, 3-d ] pyrimidine antifolate TNP-351 : Cytotoxic effect on methotrexate-resistant CCRF-CEM eeUs and inhibition of transformylases of de novo purine biosynthesis [ J ]. Cancer Chemotherapy and Pharmacolog, 1994,34 (4) :273 - 279.
  • 2Parenti M D, Paeehioni S, Ferrari A M, et al. Threedimensional quantitative structure-activity relationship analysis of a set of plasmodium falciparmn dihydrofolate reductase inhibitors using a pharmacophore generation approach [ J ]. J Med Chem, 2004,47 : 4258 - 4267.
  • 3Taylor E C, Patel H H, Junt J G. A one-step ring tansformation/ring annulation approach to pyrrolo [ 2,3d] pyrimidines. A new synthesis of the potent dihydrofolate reductase inhibitor TNP-351 [ J ]. J Org Chem, 1995,60 : 6684 - 6687.
  • 4Gangjee A, Lin X, Sherry F. Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-pyrrolo [ 2,3-d ] pyrimidines as dihydrofolate reductase inhibitors [ J ]. J Med Chem, 2004,47 : 3689 - 3692.
  • 5Gangjee A, Lin X, Roy L, et al. Synthesis of N- { 4- [ ( 2,4-diamino-5-methyl-4, 7-dihydro-3H-pyrrolo [ 2, 3-d] pyrimidin-6-yl ) thio ] benzoyl } -L-glutamic acid and N- { 4- [ ( 2-amino-4-oxo-5-methyl-g, 7-dihydro-3Hpyrrolo [ 2,3-d ] pyrimidin-6-yl ) thio ] benzoyl } -L-glu- tamic acid as dual inhibitors of dihydrofolate reductase.and thymidylate synthase and as potential antitumor a- gents [ J]. J Med Chem,2005 ,48 :7215 - 7222.
  • 6Gangjee A, Zeng Y, Talreja T J, et al. Design and synthesis of classical and nonclassical 6-arylthio-2,4- diamino-5-ethylpyrrolo [ 2,3-d ] pyrimidines as antifolates [ J ]. J Med Chem,2007,50:3046 - 3053.
  • 7Gangjee A, Hiteshkumar D, Queener S F, et al. The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d] pyrimidine containing classical and non- classical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents[J]. J Med Chem ,2008 ,51:4589 -4600.
  • 8Rosowsky A, Fua H, Queener S F. Synthesis of new 2,4-diamino-7H-pyrrolo [ 2, 3-d ] pyrimidines via the taylor ring transformation/ring annulation strategy [ J ]. J Heterocyclic Chem,2001,38 : 1197 - 1202.
  • 9Rosowsky A, Chen H, Fua H, et al. Synthesis of new 2,4-diaminopyrido [ 2,3-d ] pyrimidine and 2,4-diaminopyrrolo [ 2,3-d ] pyrimidine inhibitors of pneumocystis carinii, toxoplasma gondii, and mycobactefium avium dihydrofolate reductase [ J ]. Bioorg Med Chem, 2003,11:59 -67.
  • 10Gangjee A, Ye Z, Queener S F. Synthesis of three carbon atom bridged 2,4-diaminopyrrolo [ 2,3-d ] pyrimidines as nonclassical dihydrofolate reductase inhibiters [ J ]. J Heterocyclic Chem, 2005,42 : 1127 - 1133.

同被引文献6

引证文献2

二级引证文献1

合成化学
2011年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部