摘要
目的比较伊伐布雷定(Iva)和阿替洛尔(Ate)治疗对大鼠心梗后冠脉储备的保护作用有无差异。方法受试大鼠分为假手术(sham)组、心肌梗死(MI)组、MI+Iva组和MI+Ate组,药物治疗在诱导心肌梗死后开始,疗程28 d。比较大鼠的心梗面积,以及治疗前后的心率、冠脉储备等情况。结果三组心梗大鼠之间基础心率、梗死面积占心室面积的比例均无统计学差异;与MI组相比,术后第28天MI+Iva组和MI+Ate组的心率明显减慢;而MI+Iva组和MI+Ate组相比,术后第28天的心率减慢程度没有统计学差异。与sham组相比,MI组无论游离壁还是室间隔的冠脉储备都显著降低,MI+Ate组室间隔的冠脉储备也显著降低。MI+Iva组无论游离壁还是室间隔的冠脉储备都显著高于MI组和MI+Ate组。结论 Iva治疗对大鼠MI后冠脉储备的保护作用优于Ate。
OBJECTIVE We compared the ivabradine and atenolol in preserving Coronary reserve of infarcted rats. METHODS 12-month-old male Sprague-Dawley rats were randomly divided into 4 groups： sham group, MI group, MI ＋ Iva group and MI ＋ Ate group. Medical treatment was immediately begun following infarction and continued until the 28th day. Infarction area, heart rate and coronary reserve were compared among groups. RESULTS There were no statistical differences among the 3 infarcted groups with in- farction size and baseline heart rate. Heart rates 28 d later were significantly lower in both MI ＋ Ate group and MI ＋ Iva group compared to MI group. However, there was no statistical difference between the two medicine treated groups. Compared with the sham group, the coronary reserve of both the free wall and the ventricular septum in the MI group were significantly lower, and the coronary reserve of the ventricular septum in the MI ＋ Ate group was also significantly lower. The coronary reserve of both the free wall and the septum in the MI ＋ Iva group were higher, compared with both the MI group and the MI ＋ Ate group. CONCLUSION Iva preserves the coronary reserve of infarcted rats better than Ate treatment.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2011年第6期426-429,共4页
Chinese Pharmaceutical Journal
