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皮瓣缺血-再灌注损伤的机制研究进展 被引量:12

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摘要 缺血-再灌注损伤是导致皮瓣移植术后皮瓣坏死的主要原因之一。目前研究显示,氧自由基等活性氧物质生成、中性粒细胞聚集介导炎症反应、一氧化氮作用、钙超载及能量代谢障碍、细胞凋亡等因素是造成皮瓣缺血-再灌注损伤的可能机制,这些机制相互协同促进,形成连锁反应并不断扩大化,加重皮瓣组织损伤。该文就皮瓣缺血-再灌注损伤机制作一综述。
出处 《国际骨科学杂志》 2011年第2期108-110,126,共4页 International Journal of Orthopaedics
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参考文献46

  • 1Harder Y, Amon M,Lachke MW, et al. An old dream revitalised: preconchtioning strategies to protect surgical flaps from critical ischaenia and ischaernia -reperfusion injury. J Plast Reconstr Aesthet Surg, 2008; 61(5) :503-511.
  • 2Yoshida WB, Campos EPA Ischernia and reperfusion in skin flaps: effects of mannitol and vitamin C in reducing necrosis area in a rat experimental model. Acta Or Bras, 2005; 20(5):358-363.
  • 3SSemionow M, Arslan E Ischemia/reperfusion injury: a review in relation to free tissue transfers. Microsurgery, 2004; 24(6):408-475.
  • 4Moran SI,Serletti JM (utcome comparison between free and pedicled TRAM flap breast reconstruction in the obese patient. Plast Reconstr Surg. 2001; 108 (7) :195-196.
  • 5Rand-Luby I,Pommier RF, Williams ST, et al. Improved outcome of surgical flaps treated with topical dimethylsulfoxide. Ann Surg, 1996;224(4):583-589.
  • 6Zingarelli B. Ischemia-reperfusion injury[ A] In: Wheeler DS, Wong HR. Shanley TP, eds. Science and Practice of Pediatric Critical Care Medicine[M]. London: Springer-Verlag, 2009:181-192.
  • 7Montalvo-Jave EE, Escalante-Tattersfield T, Ortega-Salgado JA, et al. Factors in the pathophysiology of the liver ischemia-reperfusion injury. J Surg Res, 2008; 147(1):153-159.
  • 8van den Heuvel MG, BuunnanW、,Best A, et al. Review: Ischaentia -reperfusion injury in flap surgery. J Plast Reconstr Aesthet Surg, 2009; 62(6) : 721-721.
  • 9Shin MS, Angel MF, Im Np, et al. Effects of 21-aminosteroid U74389F on skin -flap survival after secondary ischemia. Plast Reconstr Surg, 1994; 94(5):661- 666.
  • 10Chang SY, Huang JJ, Tsao CK, et al. Does ischernia time affect the outcome of free fibula flaps for head and neck reconstruction? A review of 116 cases. Plant Reconstr Surg, 2010; 126(6):1988-1995.

二级参考文献24

  • 1黄凯,陈扬,陈龙.肺缺血再灌注损伤细胞凋亡的研究进展[J].福建医药杂志,2006,28(1):84-86. 被引量:3
  • 2Perlman H,Maillard L,Krasinski K,et al. Evidence for the rapid onset ofapoptosis in the medial smooth muscle cells after balloon injury[J]. Circulation,1997,95:981.
  • 3Gottlieb RA,Burleson KO,Kloner RA,et al. Reperfusion injury induces apoptosis in rabbit cardiomyocytes [J ].J Clin Invest,1994,94: 1621.
  • 4Kuo PC,Drachenberg CI, de la Torte A,et al. Apoptosis and hepatic allograft reperfusion injury[J].Clin Transplant, 1998,12(3):219.
  • 5Borghi S,Scoazec JY,Durand F,et al. Apoptosis after ischemia reperfusion in human liver allografts[J].Liver Transpl Surg,1997,3(1):407.
  • 6Tanaka M,Ito H,Adachi S,et al.Hypoxia induces apop tosis with enhanced exepressinon of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes[J].Circ Res,1994,75(3):426.
  • 7Shimizu S,Nagayama T,Jin K L,et al.Bcl-2 Antisence Treatment Prevents Induction of Tolerance to Focal Ischemia in the Ratin Brain[J].J Cereb Blood Flow Metab,2001,21 (3) : 233-236.
  • 8Ruiz Gines JA,Lopez Ongil S,Gonzalez Ruhio M,et al.Reactive oxygem species induce proliferation of bovine aortic endothelial cells[J].J Card iovasc Pharmacol,2000,35(1): 109-113.
  • 9Nordlie MA,Wold LE, Simkhovich BZ,et al.Molecular aspects of ischemic heart disease: ischemia / reperfusion-induced genetic changes and potential applications of gene and RNA interference therapy[J]. J Cardiovasc Pharmacol Ther,2006,11 (1): 17-30.
  • 10Leist M, Gantner F,Bohlinger I,et al.Murine hepatocyte apoptosis induced in vitro and vivo by TNF-1pha requires transcriptional arrest [J].J Immunol, 1994,153 (4): 1778-1782.

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