摘要
目的观察通阳活血方对慢性充血性心力衰竭(心衰)患者心功能的影响。方法将60例符合入选标准的慢性心衰患者随机分为治疗组和对照组,各30例。对照组根据病情给予西医基础治疗(强心剂、利尿剂、血管紧张素转化酶抑制剂或血管紧张素受体拮抗剂、β受体阻滞剂及硝酸酯类药物),治疗组在对照组治疗基础上加服通阳活血方,疗程3周,分别于治疗前后检测患者血浆脑钠肽(BNP)水平并对患者进行6分钟步行试验(6MWT)。结果两组患者治疗后血浆BNP水平均较治疗前明显降低(P<0.01),且治疗组降低更显著(P<0.05);两组患者治疗后6MWT步行距离均较治疗前增加(P<0.01),且治疗组优于对照组(P<0.05)。结论通阳活血方能明显降低心衰患者血浆BNP水平,改善患者心功能,中西医结合治疗慢性心衰较单纯西医治疗效果更佳。
Objective To observe the effect of Tongyang Huoxue Formula（Formula for activating yang and promoting blood circulation）on the cardiac functions of the patients with chronic congestive heart failure（CHF）.Methods Sixty CHF patients were randomized into two groups,control group and treatment group,with thirty in each.The western conventional therapy（cardiotonic,diuretic,angiotension-converting enzyme inhibitor,angiotension receptor blocker,β-receptor blocker,and nitrate medications）was applied to the control group,while the combination of western conventional therapy with Tongyang Huoxue Formula was given to the treatment group for three weeks.Before and after treatment,the brain natrium peptide（BNP）of plasma was determined and the 6-minute walk test（6MWT）was carried out to observe the effect of treatment.Results After treatment,the level of plasma BNP of both groups was significantly lowered with statistical difference（P0.01）,and changes in the treatment group was more significant（P0.05）.The walk distance of 6MWT of both groups was increased（P0.01）and the treatment group was superior to the control group,the difference was all statistically significant（P0.05）.Conclusion Tongyang Huoxue Formula significantly reduces the level of plasma BNP and enhances the heart functions of the patients.The effect of the integrated therapy is better than that of western therapy only for CHF.
出处
《中医杂志》
CSCD
北大核心
2011年第7期566-569,共4页
Journal of Traditional Chinese Medicine
基金
"十一五"国家科技支撑计划"名老中医临证经验
学术思想传承研究"项目(2007BAI10B01-093)
北京中医药"薪火传承3+3工程"(830104)
关键词
中西医结合疗法
慢性充血性心力衰竭
通阳活血方
脑钠肽
6分钟步行试验
integrated TCM-WM therapy
chronic congestive heart failure
Tongyang Huoxue Formula（formula for activating yang and promoting blood circulation）
brain natrium peptide（BNP）
6-minute walk test（6MWT）
