摘要
目的探讨异位内膜上皮细胞分泌CA-125与子宫内膜异位症血清及腹水中升高的CA-125水平间的关系。方法采用酶联免疫吸附试验法测定12例异位内膜和在位内膜（对照组）上皮细胞分泌的CA-125含量。结果异位及在位内膜上皮细胞分泌相似量的CA-125，分别为（511.19±169．20）μU／cell和（698．58±294．52）μU／cell，两者间无显著差异（P＞0.05）。异位内膜上皮细胞分泌的CA-125与内异评分呈正相关（P＜0．05）。结论异位病灶分泌的CA-125是子宫内膜异位症患者血清及腹腔液中CA-125升高的原因之一，异位内膜上皮细胞分泌CA-125随疾病程度加重而升高。
Objective To investigate if the CA-125 secretion by ectopic endometrial epithelial cells is potential source of the elevated concentrations of CA-125 in serum and peritoneal fluid. Methods Twelve normal women as control, and twelve women with endometriosis were enrolled for study. CA-125 levels in supernatant of cultured from ectopic and normal endometrial epithelial cells were measured by enzyme - labeled immunosorhent assay (ELISA). Results CA-125 was secreted in similar concentrations by epithelial cells from both tissue types. The mean levels of CA-125 in ectopic and norma] endometrial were (511.19±169.20) μ IU / cell and (698.58±294.52) μ IU / cell, respectively (P<0.05).There was no significant difference. But the correlation between CA-125 secretion by ectopic endometrial and the scoring of endometriosis was positive (P<0.05).Conclusion The production of CA-125 by ectopic implants of endometriosis is likely to be a contributing factor of the elevated serum and peritoneal fluid levels of CA-125. The higher was scoring, the higher was production of CA-125 by ectopic implants.
出处
《中国实验诊断学》
1999年第4期153-155,共3页
Chinese Journal of Laboratory Diagnosis
