摘要
目的：比较柳氮磺胺吡啶 联合甲氨喋呤与单用甲氨喋呤治疗强直性脊柱炎的临床疗效与副反应。方法：回顾性总结了１０ 例甲氨喋呤对照组与１６ 例柳氮磺胺吡啶联合甲氨喋呤治疗组治疗１ 年后，对腰背痛、晨僵时间、外周关节痛、胸廓扩张度、 Ｓｃｈｏｂｅｒ 试验、血沉、 Ｃ 反应蛋白、 Ｘ 线骶髂关节改变的影响。结果：治疗组总有效率优于对照组，尤其对改善晨僵时间、外周关节痛、枕墙距、 Ｃ Ｒ Ｐ 优于对照组。两组副反应均较轻，无显著差异。结论：柳氮磺胺吡啶 联合甲氨喋呤治疗强直性脊柱炎的临床疗效优于单用甲氨喋呤对照组。两组副反应均较轻，安全性与耐受性相似。
Aim:to compare MTX+SASP with MTX on clinical efficacy and adverse reaction in the treatment of ankylosing spondylitis.Methods:The changes in lumbar pain,morning stiff time,peripheral joint pain, thoracic expansion,Schober test,ESR,CRP,and radioactive sacroiliitis were analysed retrospectively after 1 year when 10 cases of AS control group were treated with MTX and 16 cases of AS treatment group were treated with MTX+SASP.Results:The treatment group was superior to the control group in total efficacy rate,especially in bettering morning stiff time,peripheral joint pain,occipito wall gap and CRP.Both groups had similar adverse reactions with no significant difference.Conclusions:MTX+SASP has higher efficacy in treating AS than MTX,but possesses similar adverse reaction and tolerence.
出处
《颈腰痛杂志》
1999年第3期189-190,共2页
The Journal of Cervicodynia and Lumbodynia
