摘要
目的:建立双侧下颌骨牵张成骨区快速正畸牙移动的实验动物模型,为其后的系列研究建立可靠的实验平台。方法:选择8只牙列完整的Beagle犬,其中4只犬建立双侧下颌骨牵张成骨动物模型,牵张完成后即刻以150g力远中移动下颌第三前磨牙进入牵张成骨区;另外4只犬拔除双侧下颌第四前磨牙后3个月,以150g力远中移动下颌第三前磨牙。实验中,每周加力1次,拍摄X线片并记录牙移动速率。牙移动8周后,观察实验牙及其牙周组织特点。结果:接受牵张成骨手术的4只犬,双侧下颌骨均被成功延长1cm,前牙出现反合,无实验犬死亡。实验牙借助自制的持续加力装置移动进入牵张成骨区。实验组牙移动显著快于对照组,X线观察实验组牙移动进入牵张成骨区,牙根未见明显吸收。组织学观察压力侧牙槽骨和牙周膜未出现不可逆性损伤。结论:以Beagle犬为实验对象,用成品牵张成骨器借助种植支抗钉和自制的牙移动装置远中移动下颌第三前磨牙,可建立可靠的动物模型。
PURPOSE： This study was to establish an animal model of tooth moving into newly distracted bone after mandibular distraction osteogenesis in Beagle dog.METHODS： Eight Beagle dogs were selected in this study,four dogs（experiment group） underwent 10 mm of bilateral mandibular distraction osteogenesis.After 0-week consolidation periods,the bilateral third premolars were moved distally into the regenerated bone with 150g orthodontic force for 8 weeks.Four dogs（control group） were extracted the fourth premolar.Twelve weeks later,the bilateral third premolars were moved distally with 150g orthodontic force for 8 weeks.The force was checked and activated weekly.The characters about the third premolar movement style,movement rate and alveolar bone remodeling were investigated by the following methods： measuring the distance of tooth movement,radiographic examination and histological examination.RESULTS： The experimental procedure was well tolerated in all animals and 10 mm distraction length was successfully achieved.A dog model for tooth moving into newly distracted bone was established successfully.The rate of movement in the experimental group was faster when the teeth were moved into newly distracted bone after 0-week consolidation periods than that in the control group.We observed significant root resorption extending into the cementum with 150g orthodontic force in the group after 0-week consolidation periods.CONCLUSION： Beagle dog is a satisfactory animal on the experimental study for tooth moving into newly distracted bone.
出处
《上海口腔医学》
CAS
CSCD
2011年第1期21-25,共5页
Shanghai Journal of Stomatology
基金
上海市重点学科建设项目(S30206)~~
关键词
下颌骨
牵张成骨
牙移动
动物模型
犬
Mandible
Distraction osteogenesis
Tooth movement
Animal model
Beagle dog
