摘要
近十年来,国内外在血液病的研究如造血干细胞的生物学特性,血液病表观遗传学调控机制及临床干预措施,血液病的分子诊断及靶向治疗,造血干细胞移植方案的优化、替代供体的选择及并发症防治等方面取得了重要进展。未来血液病学的发展方向为:发现造血及淋巴组织肿瘤中的分子遗传学异常,以期为疾病的早期诊断提供依据;关注干细胞与造血微环境(niche)的关系、血液病发病机制与异常基因的表达调控,以及相关的转化医学研究;探索新的治疗靶点、靶向治疗药物、细胞学诊治策略,通过多中心临床研究获取我国血液病患者诊治的循证医学证据;进一步提高造血干细胞移植的临床疗效,减少并发症,预防疾病复发。上述研究成果不仅将造福血液病患者,亦具有重要的军事医学意义。
Over the past decade,promising progress has been made in hematology by domestic and oversea researchers,such as the biological features of hematopoietic stem cells,underlying mechanism involving epigenetics of hematological disease and the intervention measures thereof,molecular diagnosis and targeted therapy,optimization of therapeutic protocol for hematopoietic stem cell transplantation,selection of alternative donors,and prevention and treatment of complications post transplantation.Development of hematology in the future will focus on the following fields.Chromosome translocation and gene mutation are key diagnostic criteria in the new version of WHO classification of tumors of hematopoietic and lymphoid tissues.And the detections of these aberrant alterations make tailored therapy and follow-up of therapeutic effects possible.And more attention should be placed on the translational research of stem cell and niche,as well the pathogenesis of hematopoietic diseases including aberrant histone acetylation,DNA methylation and expression of abnormal micro RNA,which will promote the further understanding of the pathogenesis of hematopoietic diseases and made targeted therapy as well as personalized medicine possible.In addition,the prevention and treatment of complications of stem cell transplantation are made through the optimization of conditioning regimen,the combination of different drugs as well as cellular immunization,which should greatly improve the effects of hematopoietic stem cell transplantation,and bring benefits to the patients and can be utilized in the medical rescue in military events.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2011年第3期206-210,共5页
Medical Journal of Chinese People's Liberation Army
基金
国家自然科学基金(30700333
30873042
30871100
30800488
C140402
C171010)
上海市科委基金(03DJ14020
05DZ19327
07ZR14146
08JC1406500)
关键词
造血细胞移植
表观遗传学
诊断
治疗
hematopoietic stem ceil transplantation
epigenetics
diagnosis
therapy
