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Th17细胞在皮肤病的研究进展 被引量：2

T helper 17 （Th17） cells in skin diseases
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摘要 Th17细胞不同于Th1、Th2细胞.它由记忆CD4＋T细胞、初始T细胞等在IL-6和转化生长因子β、IL-1β或IL-23的作用下分化而来的.成熟的Th17细胞分泌IL-17、IL-22等多种细胞因子,在自身免疫疾病、宿主防御、炎症、肿瘤、移植物排斥等多种病理过程中起着重要的作用.概述Th17细胞的分化、相关细胞因子,以及在皮肤病发病机制中的作用. Th17 cells are different from Th1 and Th2 cells. They are differentiated from memory CD4＋T cells and naive T cells induced by interleukin （IL）-6, transforming growth factor （TGF） 3, IL-1β or IL-23.Mature Th17 cells can secrete many cytokines, such as IL-17, IL-22, etc, and play a crucial role in the pathological process of autoimmune diseases, host defense, inflammatory diseases, tumors and graft-versus-host diseases. This review presents the differentiation and related cytokines of Th17 cells as well as their roles in the pathogenesis of skin diseases.
作者 李泓馨 林麟
机构地区 中国医学科学院北京协和医学院皮肤病研究所
出处 《国际皮肤性病学杂志》 2011年第2期88-91,共4页 International Journal of Dermatology and Venereology
关键词 TH17细胞 白细胞介素17 皮肤疾病 Th17 cells Interleukin-17 Skin diseases
分类号 R751 [医药卫生—皮肤病学与性病学]
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参考文献27

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同被引文献32

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国际皮肤性病学杂志
2011年 第2期

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