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eNOS磷酸化与酶活性及中药介入 被引量：2

eNOS activity regulation associated with its' phosphorylated modification and intervention of TCM
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摘要 作为内皮源性血管舒张因子,内皮源性一氧化氮合酶(endothelial nitric oxide synthase,eNOS)衍生的一氧化氮(nitric oxide,NO)在维持血管稳态和预防血管病变中起着至关重要的作用。eNOS的活性调控涉及复杂而精密的信号通路及分子机制,尤其是多个不同位点的氨基酸残基的磷酸化在其活性调控中发挥关键作用。该文就其主要的氨基酸残基的磷酸化对eNOS酶活性的影响及相关的信号通路,以及中药对其干预的研究现状做一综述。 Nitric oxide（NO）derived from endothelial nitric oxide synthase（eNOS）played a key role in vascular homeostasis and prevention of vascular diseases.The regulation of eNOS activity was complex and precise,especially phosphorylation of different sites of amino acid residues engaged in the molecular mechanisms and signaling pathways.This paper focused on the role of main phosphorylated amino acid residues of eNOS for activity regulation,related signaling pathways and intervention of TCM.
作者 史海霞 刘俊 薛永亮 俞林花 聂绪强 卞卡
机构地区 上海中医药大学穆拉德中药现代化研究中心 美国德克萨斯大学休斯敦医学院综合生物及药理学系
出处 《中国药理学通报》 CAS CSCD 北大核心 2011年第3期304-308,共5页 Chinese Pharmacological Bulletin
基金 国家科技部“十一五”支撑计划项目(No2006BAI11B08-03) 国家中医药管理局重大专项(No2009ZX09311-003) 上海市科委中药现代化项目(No08DZ1972104)
关键词 内皮源性一氧化氮 内皮源性一氧化氮合酶 氨基酸残基 磷酸化 活性调控 中药干预 endothelial nitric oxide endothelial nitric oxide synthase amino acid residue phosphorylation activity regulation intervention of TCM
分类号 R-05 [医药卫生] R282.71 [医药卫生—中药学]
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共引文献11

同被引文献38

  • 1倪布清,张石江,朱煜明,张宁,王虹,解卫平.新型KATP通道开放剂埃他卡林对人肺动脉平滑肌细胞增殖的影响[J].国际呼吸杂志,2007,27(12):903-906. 被引量：5
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二级引证文献12

中国药理学通报
2011年 第3期

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