摘要
目的:探讨头颈部胚胎型横纹肌肉瘤的临床特点、诊断、治疗及预后。方法:回顾性分析上海交通大学医学院附属第九人民医院2000-09—2010-10收治的12例头颈部胚胎型横纹肌肉瘤患者的临床资料。结果:12例患者中9例获得随访。5例术前化疗患者中3例短期疗效达到PR,1例达到MR,化疗有效率达到60%;8例患者行手术治疗,其中2例手术+化疗+放疗患者生存期分别为37个月和40个月,1例手术+尼妥珠靶向治疗患者,生存期已达14个月,仍在随访中;1例单纯手术患者,术后半年死于肿瘤复发。结论:该病缺乏特征性临床表现。手术结合放疗、化疗的综合序列治疗被认为是目前治疗头颈横纹肌肉瘤的有效手段,生物靶向治疗可能是今后治疗该疾病的一个方向。
Objective：To explore the clinical feature,diagnosis,treatment and prognosis of embryonal rhabdomyosarcoma of the head and neck.Methods：We analyzed twelve cases of Embryonal Rhabdomyosarcoma of the head and neck in the Ninth People＇s Hospital,School of Stomatology,Shanghai Jiaotong University from 2000-09 to 2010- 10.Results：9 patients had the follow-up information,5 were treated by chemotherapy before surgery,3 patients got PR and 1 got MR,the effective rate was 60%.8 patients underwent surgery,2 of whom receiving further chemotherapy and radiotherapy survived 37 and 40 months.1 patient who got surgery combined with target therapy has survived 14 months and is still being followed up.1 patient died half a year after operation without any other treatment.Conclusion： Combined and sequential therapy has been considered to be an effective method in treatment of rhabdomyosarcoma of head and neck so far.The target therapy may become a main method in the future.
出处
《口腔颌面外科杂志》
CAS
2011年第1期19-23,共5页
Journal of Oral and Maxillofacial Surgery
基金
上海市科学技术委员会科研资助项目(10410711200)
关键词
口腔颌面-头颈部
胚胎型
横纹肌肉瘤
综合序列治疗
靶向治疗
oral and maxillofacial-head and neck
embryonal
Rhabdomyosarcoma
Combined and sequential therapy
target therapy
