摘要
T细胞是体内重要的免疫细胞,T细胞介导的细胞免疫应答参与了肿瘤、自身免疫性疾病等疾病的病理生理过程.研究T细胞分化和功能调控机制将有助于阐明相关疾病的发病机制,并为疾病防治提供思路.近来有国外研究显示,早期胚胎发育过程中的关键成形素(mophorgen)——Sonic hedgehog(SHH)不仅调控T细胞发育的各个阶段,还对外周成熟T细胞的增殖、活化产生影响,因此可能是T细胞分化和功能实现的重要调控机制之一.本研究就SHH信号通路及其生物学功能、SHH对T细胞分化各个阶段的调控及功能的影响作一综述.
T cell is an important immune cell.T cell-mediated immunity has been involved in the pathophysiology of many diseases such as cancer,autoimmune disease and so on.Study on regulation mechanisms of T cell development and function will not only contribute to uncover mechanism of diseases,and also provide ideas for prevention and treatment of related disease.Recently,researches abroad have showed that sonic hedgehog（SHH）,acting as a key mophorgen during development of early embryo,not only regulated T cell development in every stages but also had effect on proliferation and activation of peripheral mature T cell.SHH maybe an important regulator to T cell development and function.Here we review the SHH signaling pathway and it＇s biological function,regulation of SHH on T cell development and function in this paper.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
北大核心
2011年第1期105-108,共4页
Journal of Jinan University(Natural Science & Medicine Edition)
基金
国家自然科学基金资助项目(81000923)
广东省医学科学技术研究基金项目(B2009117)
广东高校优秀青年创新人才培育项目(2009400)
