摘要
目的:探讨儿童与成人系统性红斑狼疮(SLE)的临床表现和实验室指标的差异。方法:对224例SLE患者(成人160例,儿童64例)的临床资料进行回顾性分析。结果:临床表现中儿童的口腔溃疡、皮肤血管炎、肺部受累、精神神经系统症状、肾脏损害发生率明显高于成人组(P<0.05),而关节肌肉损害、蝶形红斑的发生率明显低于成人(P<0.05);实验室检查中儿童补体降低发生率明显高于成人组(P<0.05)。结论:儿童SLE发病多不典型,易误诊,而且系统损害较成人严重,预后较差。
Objective： To explore the differences of the clinical features and laboratory test between children and adult patients with systemic lupus erythematosus（SLE）.Methods：A retrospective analysis was performed on clinical data of 224 SLE patients（160 adult,64 children）.Results： In clinical figures,oral ulcers,skin vasculitis,pulmonary involvement,mental nervous system symptoms,kidney damage in children were significantly higher（P0.05）,but joint muscle damage and butterfly erythema were significantly less than those in adult patients（P0.05）;In laboratory indicators,the incidence of complement reduction in children was significantly higher than that in adults（P0.05）.Conclusion： Children SLE is not typical and misdiagnosed easily,the system damages are severe and the prognosis is poor.
出处
《天津医科大学学报》
2011年第1期63-64,67,共3页
Journal of Tianjin Medical University
关键词
红斑狼疮
系统性
儿童
成人
Lupus erythematosus
systemic
Children
Adult
