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MPTP/MPP^+诱导的帕金森病实验模型的研究进展 被引量：9

MPTP/MPP^+-induced Experimental Model of Parkinson Disease
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摘要 建立一个稳定可靠的实验模型对研究帕金森病(PD)的发病和治疗是尤其必要的。自从发现1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)能在人类诱发PD以来,人们对其神经毒性作了大量研究。MPTP及其有效成分1-甲基-4-苯基吡啶离子(MPP+)对中脑黑质多巴胺能神经元有选择性的破坏作用,从而发挥其诱导PD的毒性作用。在过去的几十年里对MPTP/MPP+诱导的PD实验模型的研究取得了显著的进展,目前MPTP/MPP+诱导的PD实验模型已广泛地用于PD研究。 The development of a stable and reliable experimental model is particularly necessary for the study of the pathogenesis of Parkinson disease（PD） and the development of therapeutic strategies.As 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine（MPTP） has been shown to induce PD in humans,the neurotoxicity of MPTP has been extensively studied.It is found that MPTP and its active neurotoxic metabolite 1-methyl-4-phenyl-pyridinium（MPP＋） can selectively damage substantia nigra dopaminergic neurons,inducing the neurotoxicity in PD.The study of MPTP/ MPP＋-induced PD experimental model has made great progress in the past decades.Currently,MPTP/ MPP＋-induced PD experimental models have been widely used in PD study.
作者 解洪荣 张玉花 李雪松 王立崚 胡林森
机构地区 大庆油田总医院神经内科 吉林大学第一医院神经内科 大庆油田总医院CT室
出处 《医学综述》 2011年第5期669-672,共4页 Medical Recapitulate
关键词 1-甲基-4-苯基-1 2 3 6-四氢吡啶 1-甲基-4-苯基吡啶离子 帕金森病 实验模型 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine 1-methyl-4-phenylpyridinium ion Parkinson disease Experimental model
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献26

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同被引文献97

  • 1高云朝,林祥通.MPTP帕金森病动物模型研究进展[J].中国实验动物学报,2005,13(4):261-265. 被引量：13
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医学综述
2011年 第5期

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