摘要
度 AD患者之间在除信息量、流利性、系列语言、视读、听字辨认等的所有亚项上差异均显著 (p<0 .0 5 ) ,但尚未出现经皮质感觉性失语 ;12例重度 AD患者 (CDR=3 )与中度 AD组之间在除流利性的所有亚项上差异均显著 (p<0 .0 5 ) ,有 6例类似于经皮质感觉性失语 ,5例类似于韦尼克失语 ,1例类似于命名性失语 ;痴呆严重程度与脑萎缩范围呈正相关 ,r=0 .5 5 3 p<0 .0 1。结论 :AD的语言障碍在各阶段表现为不同形式的流利型失语 ,其变化与不同程度的脑萎缩有关。
Objective:to study features of language disorders in Alzheimer’s Disease(AD)with different degrees.Method:31 patients diagnosed as“probable AD”by NINCDS-ADRDA criteria were examined by Aphasia Battery of Chinese(ABC)and several other neuropsychological tests.The degree of their AD was determined by Clinical Dementia Rating(CDR). Results:object naming,retell,sequential commands,spontaneous writing were significantly different between 9 patients with mild AD and 11 normal controls(p<0 05),but there was no anomic aphasia in mild AD.Except for information content,series speech,visual reading,listen words identify,every other subtitiles of aphasia were significantly different between patients with mild AD and 10 patients with moderate AD(p<0 05),but patients with moderate AD had no transcortical sensory aphasia yet.Except for fluency in speech,other subtitles of aphasia showed difference between moderate and severe AD(p<0 05).Among 12 patients with severe AD,6 were similar to transcortical sensory aphasia,5 similar to Wernicke aphasia and the other one similar to anomic aphasia.The severity of dementia was positively correlated with the degree of brain atrophy(r=0 55,p<0 01).Conclusion:language disorders of AD shows different forms of fluency aphasia in each stage.
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
1999年第5期263-265,共3页
Chinese Mental Health Journal
关键词
语言障碍
失语
神经心理学
老年性痴呆
Alzheimer′s Disease language disorders aphasia neuropsychology
