摘要
目的 :探讨恶性肿瘤病人静吸复合麻醉中血过氧化物的变化。方法 :观察 2 6例恶性肿瘤病人和 2 2例非肿瘤对照病人静吸复合麻醉中P LPO和E LPO及P SOD和E SOD变化 ,以及术中HR、MAP变化。结果 :两组LPO持续上升 ,SOD持续性下降 ,但无显著性差异 ,LPO于同一时间恶性肿瘤组明显高于非肿瘤组 ,SOD明显降低 ,而HR、MAP变化无显著性差异。结论 :静吸复合麻醉中心血管功能稳定 ,手术时间不长的情况下LPO、SOD无明显改变。恶性肿瘤组与非肿瘤组显著差异 ,并非由于麻醉的作用 ,而与恶性肿瘤病人术前自由基、脂质过氧化反应加速等因素有关。
Objective: To examine the changes of SOD and LPO in plasma and erythrocyte in cancer patients under combined intravenous inhalational anesthesia. Methods: Both plasma and erythrocyte LPO (P LPO and E LPO), and both plasma and erythrocyte SOD (P SOD and E SOD) were measured before anesthesia, after intubation, one hour after anesthesia and at the end of surgery in 26 cancer patients. 22 non cancer patients served as control. Results: Although there were progressive increase of P LPO and E LPO, and progressive decrease of P SOD and E SOD in both groups, no significant difference was observed as compared with their baseline measurements. At each point of measurement, the cancer group had significantly higher P LPO and E LPO, and significantly lower P SOD and E SOD than that of the non cancer group. Conclusion: The combined intravenous inhalational anesthesia doesnt cause significant change of LPO and SOD in either cancer patients or non cancer patients, while the cardiovascular function is kept to be stable during relatively short period of surgery.
出处
《临床麻醉学杂志》
CAS
CSCD
1999年第4期201-205,共5页
Journal of Clinical Anesthesiology
