摘要
目的 :探讨补肾法对更年期综合征的治疗作用机制。方法 :以去卵巢成年♀大鼠为模型 ,补肾药片分高、中、低不同剂量对模型大鼠进行治疗 ,从神经、内分泌、免疫三大系统进行观察。结果 :①调节植物神经功能 :补肾药片不同剂量组均可使去卵巢后升高的脑组织 5 -HT、5 -HIAA的含量明显下降 (P <0 .0 5或P <0 .0 1) ,能使去卵巢后升高的 5 -HT/NE的比值降至正常组水平。②调节生殖内分泌 :补肾药片大、中剂量均能明显增加去卵巢后的子宫重量系数 (P <0 .0 5 ) ,减轻去卵巢后子宫组织的萎缩程度 ;去卵巢后大鼠血清E2水平明显降低 (P <0 .0 1) ,FSH、LH水平明显升高 (P <0 .0 1) ,补肾药片不同剂量组均能使去卵巢后升高的FSH、LH水平明显降低 (P <0 .0 5 )。③提高免疫力 :补肾药片大、中剂量均能升高去卵巢大鼠血清IL - 2含量。结论 :补肾药能调节植物神经功能 ,调节生殖内分泌 ,提高免疫能力 ,多途径多环节地调节神经 -内分泌 -免疫网络。
Objectives:To study the therapeutic action for invigorating the kidney on climcateric syndrome. Methods:It used mature female rats with anovaria as models.they were taken medicine by the tablets for invigorating the kidney,according to high、moderate and low doses,and observed from nerous、endocrine and immune system. Results:①Regulating the fuction of plant nerve:The different dose groups,all can reduce brain organization 5-HT、5-HIAA,which were increased after arvovaria (P<0.05 or P<0.01);even they can let 5-HT/NE's ratio decrease to the normal levelgroup.②Regulating reproduction endocrine:The high、moderate doses of the tabelts for invigorating the kidney,Can evidently increase ovariprival uterus' weight coefficient (P<0.05), lighten the atrophy degree of ovary organization with anovaria. After arvovaria, the rats' serum E2 level reduced significantly (P<0.01), the level of FSH、LH was obviously increased (P<0.01) ,but the different groups of the tabelts for invigorating the kidney can reduce eviently the levels of FSH、LH that were increased after arvovaria .③Improving immunity:The high、moderate doses of the tabelts for invigorating the kidney, both can increase rats' serum IL-2 Content. Conclusions: The tablets for invigorating the kidney can regulate the faction of plant nerve and reproduction endocrine, improve immumity, regulate nerve-eadocrine-immune network by various ways and links.
出处
《湖南中医药导报》
1999年第8期32-35,共4页
Hunan Guiding Journal of Traditional Chinese Medicine and Pharmacology
关键词
更年期综合征
补肾法
中医药疗法
Climeateric syndrome
Methods for Invigorating the kidney
Network mechanism
