摘要
目的探讨羧甲基赖氨酸(CML)和可溶性糖基化终产物受体(sRAGE)水平与2型糖尿病冠状动脉钙化及其危险因素的关系。方法 101例2型糖尿病患者采用ELISA法检测sRAGE和CML水平;根据64排螺旋CT冠状动脉钙化积分(CACS)结果分为钙化组(CACS>0),无钙化组(CACS=0),并进一步分四个亚组;测定踝臂指数(ABI)、颈动脉内膜中层厚度(IMT)及糖脂指标等;所有资料均以SPSS 16.0软件进行统计分析。结果二项分类Logistic回归分析发现年龄及ABI是冠状动脉钙化独立相关因素;CACS与年龄呈正相关,与ABI呈负相关;重度钙化组sRAGE水平较无钙化组明显降低,差异有统计学意义(P<0.05)。结论 ABI可作为评估冠状动脉钙化的独立预测因子;年龄是冠状动脉钙化的独立危险因素;sRAGE是冠状动脉硬化、钙化进程中的预测指标和保护因子。
Objective To investigate the relationship between the levels of serum Nε-（carboxymethyl） lysine（CML） and soluble receptor for advanced glycation end products（sRAGE） and the coronary artery calcification（CAC）,and analyze the risk factors of coronary artery calcification in type 2 diabetes mellitus. Methods The levels of CML and sRAGE were detected by ELISA for 101 patients with type 2 diabetes mellitus;according to CAC score（CACS） measured by 64-detector computed tomography the patients were divided as CAC group（CACS0） and non-CAC group（CACS=0）,and further divided into 4 subgroups of different degrees of CAC.The clinical data of patients including intima-media thickness（IMT）,ankle-brachial index（ABI）,and the indexes of glucose and fat were collected.All data were analyzed by using SPSS 16.0 software. Results Binar Logistic regression analysis showed that the age and ABI were significantly and independently associated with CAC,and CACS was correlated positively with age and negatively with ABI.The serum sRAGE level was obviously decreased in severe CAC subgroup as compared with non-CAC group（P0.05）. Conclusion ABI could be used as an independent predictor for CAC;and age is an independent risk factor associated with CAC.The sRAGE may be a predictor and protective factor for coronary artery disease.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第4期388-390,393,共4页
Chinese General Practice
关键词
糖尿病
2型
羧甲基赖氨酸
可溶性糖基化终产物受体
冠状动脉钙化
Diabetes mellitus
type 2
Nε-（carboxymethyl）lysine
Soluble receptor for advanced glycation end products
Coronary artery calcification
