摘要
目的评价三丙烯微球在部分性脾动脉栓塞(PSE)治疗肝硬化脾功能亢进(脾亢)中的临床疗效。方法 30例肝硬化合并脾肿大、脾亢患者行PSE,16例使用明胶海绵,14例使用三丙烯微球。栓塞面积一般在40%～80%。术后随访观察患者外周血白细胞、血小板计数变化及不良反应。结果 6个月后28例患者血白细胞、血小板恢复正常,明胶海绵组有2例复发。三丙烯微球组与明胶海绵组在脾栓塞治疗中疗效无统计学差异(P>0.05),但对比明胶海绵组,三丙烯微球栓塞组术后疼痛较轻,持续时间缩短,且具有易操作的优点。结论三丙烯微球用于脾动脉栓塞治疗脾亢有效、易操作,同时能减轻术后不良反应。
Objective To evaluate partial splenic embolization（PSE） with trisacryl gelatin microsphere in treating secondary hypersplenism.Methods Thirty patients with hypersplenism were treated with PSE.The patients were randomly divided into two groups.Trisacryl gelatin microsphere used as the embolic material was employed in study group（n = 14）,while Gelfoam was employed in control group（n = 16）.The occlusive area was controlled within 50% to 80%.All patients were followed up for six months.After the PSE procedure the peripheral white blood cell（WBC） count and the platelet（PLT） count were determined,and the adverse reaction was observed.Results Six months after the treatment,both WBC and PLT counts fell to normal in 28 patients,and recurrence was seen in two patients of control group.No significant difference in clinical therapeutic results existed between two groups.However,the abdominal pain in the patients of study group was obviously mild and lasted shorter than that in the patients of control group.In performing the embolization procedure,the embolic agent trisacryl gelatin microsphere was easily to be managed.Conclusion Used as an embolic agent in partial splenic embolization for secondary hypersplenism,trisacryl gelatin microsphere is effective and safe,moreover,it is easy to be operated with fewer postoperative side effects.
出处
《介入放射学杂志》
CSCD
北大核心
2011年第2期112-115,共4页
Journal of Interventional Radiology
关键词
三丙烯微球
脾功能亢进
栓塞
栓塞材料
治疗性
trisacryl gelatin microsphere
hypersplenism
embolization
embolic material
therapy
