摘要
目的探讨功能性空肠间置代胃重建术（FJI）和P型Roux—en—Y全胃切除空肠代胃术（PR）两种不同消化道重建方式对胃癌患者全胃切除术后生活质量、营养状态及术后辅助化疗耐受性的影响。方法实施全胃切除的107例胃癌患者中，49例行FJI重建术，58例行PR重建术。其中79例患者（FJI组40例，PR组39例），术后3周按XELOX方案行辅助化疗，监测两组患者的术后消化道并发症发生率及化疗耐受性。结果107例患者均未发生严重手术并发症，无围手术期及化疗相关死亡。FJI组反流性食管炎、倾倒综合征、滞留综合征及消瘦的发生率分别为18．4％、6．1％、4．1％和8．2％，PR组分别为19．0％、19．0％、15．5％和22．4％，两组倾倒综合征、滞留综合征及消瘦的发生率差异有统计学意义（均P〈0．05）。FJI组接受辅助化疗的患者中，28例完成了6个周期的辅助化疗，中断化疗12例；PR组接受辅助化疗的患者中，19例完成了6个周期的辅助化疗，中断化疗20例。两组Ⅲ～Ⅳ度毒副反应发生率及化疗完成率差异有统计学意义（均P〈0．05）。结论FJI和PR消化道重建术安全可行，FJI组术后远期并发症的发生率低于PR组，术后辅助化疗的耐受性优于PR组。
Objective To evaluate the influence of two different types of digestive tract reconstruction on the life quality, nutritional status and tolerance to adjuvant chemotherapy after total gastrectomy in patients with gastric carcinoma. Methods The clinical data of a total of 107 patients treated in our department from January 2005 to december 2008 were analyzed retrospectively. Among them, 49 patients underwent digestive tract reconstruction with functional jejunal interposition （FJI group ） and 58 patients underwent Roux en-Y jejunal P-type anastomosis （PR group） after total gastrectomy. 79 of 107 （73.8%） patients received postoperative adjuvant chemotherapy with XELOX regimen. The digestive complications and tolerance to chemotherapy were assessed respectively. Results Neither severe complications nor surgery-related or chemotherapy-related death were observed among the 107 patients. There were statistical differences in the incidence rate of emaciation, dumping syndrome and retention syndrome between the FJI and PR groups （P 〈 0.05 ）, but no significant statistical difference in incidence rate of reflux esophagitis （P 〉 0.05）. 28 of 40 （70.0%） patients in the FJI group completed all six cycles of chemotherapy, while 12 （30.0%） patients interrupted the treatment due to chemotherapy-related toxicity. 39 patients in the PR group received chemotherapy, 19 （48.7%） of them completed 6 cycles of chemotherapy but 20 （51.3%） patients interrupted. There was a significant difference in the incidence rate of grade m/IV chemotherapeutic toxicity and completion rate of chemotherapy （ P 〈 0. 05 ）. Conclusions Both functional jejunal interposition and Roux-Y operation are reasonable and safe procedures of digestive tract reconstruction. The incidence rates of emaciation, dumping syndrome and retention syndrome are lower in the oatients with FJI, showing a better tolerance to adiuvant chemotherapy than Roux en-Y jejunal p type anastomosis.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2011年第2期126-129,共4页
Chinese Journal of Oncology
基金
广东省科技厅计划项目（20088030301079）
