摘要
以PCl5和NH4Cl为原料,利用一锅法制备了聚二氯膦腈,通过两步亲核取代反应,分别以甘氨酸乙酯和对羟基苯甲酸甲酯为亲核试剂,合成了混合取代可生物降解聚[(对羟基苯甲酸甲酯/甘氨酸乙酯)膦腈].用核磁共振波谱及红外光谱等对产物结构进行了表征.研究了甘氨酸乙酯和对羟基苯甲酸甲酯的比例及外界环境对所制备的聚膦腈降解性能的影响,并进行了体外降解实验.研究结果表明,通过改变甘氨酸乙酯和对羟基苯甲酸甲酯的比例,可获得一种降解速率可调节的生物降解膦腈聚合物.
Polydichlorophosphazene （PDCP） was synthesized from PCl5 and NH4Cl via a one-pot approach, and then further reacted with glycine ethyl ester and methylparaben via a two-step nucleophilic substitution approach to give poly[（methylparaben/glycine ethyl ester）]phosphazene （PMGP）, which was a kind of mix-substituted biodegradable polymer. NMR and FT-IR were used to characterize its structure. A series of experiments were conducted to study the effects of the ratio of methylparaben to glycine ethyl ester and the experiment conditions to the degradability of PMGP samples. The degradability of PMGP can be adjusted by altering the ratio of methylparaben to glycine ethyl ester easily.
出处
《中国科学：化学》
CAS
CSCD
北大核心
2011年第3期485-490,共6页
SCIENTIA SINICA Chimica
关键词
聚膦腈
可生物降解
对羟基苯甲酸甲酯
甘氨酸乙酯
polyphosphazene
biodegradable
methyl parahydroxybenzoats
glycine ethyl ester
