摘要
目的研究石蝉草Peperomia dindygulensis乙醇提取物中的化学成分。方法利用硅胶柱色谱、薄层制备色谱及半制备高效液相色谱法,对石蝉草乙醇提取物氯仿萃取部位中的化学成分进行分离;通过理化性质、波谱技术、混合解析等手段相结合的方法,对化合物进行结构鉴定。结果从石蝉草乙醇提取物氯仿萃取部位中分离得到2个新的聚酮类化合物,分别鉴定为(4S)-1,4-二羟基-2-(1′,13′-二酮基-十八碳-14′反式-烯基)-1-环己烯-3-酮(1)和(4S)-1,4-二羟基-2-(1′,14′-二酮基-十八碳-12′反式-烯基)-1-环己烯-3-酮(2)。结论化合物1和2均为新化合物,分别命名为石蝉草酮A和石蝉草酮B。
Objective To study the chemical constituents from Peperomia dindygulensis.Methods The chemical constituents in chloroform fraction of ethanol extract from P.dindygulensis were isolated and purified by column chromatography over silica gel column,preparative TLC,and semi-preparative HPLC.Their chemical structures were elucidated on the basis of physicochemical and spectral data.Results Two new polyketides were isolated from the chloroform extracting fraction of P.dindygulensis and identified as（4S）-1,4-dihydroxy-2-（1′,13′-diketone-octadec-14′E-ene）-1-cyclohexen-3-one（1） and（4S）-1,4-dihydroxy-2-（1′,14′-diketone-octadec-12′E-ene）-1-cyclohexen-3-one（2）.Conclusion Compounds 1 and 2 are new compounds and named as peperomadinone A and peperomadinone B
出处
《中草药》
CAS
CSCD
北大核心
2011年第3期420-423,共4页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(30901852)
国家"重大新药创制"科技重大专项资助项目(2009ZX09301-007)
上海市青年科技启明星计划项目(10QB1404000)
