摘要
目的通过诱导大鼠直立体位引起腰椎病变的实验方法来观察腰与肾的相关性,并由此认识"腰为肾之府"这一理论机制。方法将24只SD大鼠随机分为正常组、直立组及恢复体位组各8只,采用肩关节离断术、抬高食物和水的方法诱导大鼠直立,制备大鼠直立模型,9周后以X线片、血糖浓度、体重、肾组织形态为指标,观察腰椎变化对肾脏的影响。结果大鼠直立后出现下腰椎间隙变窄,椎体前缘出现唇缘样增生。直立组大鼠体重、肾小球直径、周长均较正常组显著性下降(P<0.01);直立组、恢复体位组的肾小球直径,周长较正常组均有显著性增加(P<0.01);肾组织出现病理变化,肾小球较正常组显著性增大(P<0.01)。结论大鼠直立后腰椎的变化可引发肾组织病理改变,恢复体位后有所改善,因此腰与肾关系密切,用现代实验方法验证了"腰为肾之府"中医理论。
Objective To observe the relationship between the lumbus and kidney through the experimental study on the lumbar pathological changes caused by long-term upright posture in rats,and to understand the TCM theory that the lumbus is the house of kidney.Methods Twenty-four SD rats were randomized into the normal group,the upright posture group,and the posture recovery group.The upright posture models were made with the shoulder joint amputation and elevated food and water.Nine weeks later,the changes in X-ray examination,blood glucose,body weight,and kidney morphology were observed to see the influence of pathological changes of lumbar vertebrae on the kidney.Results In the upright posture,the X-ray examination showed that the lower lumbar intervertebral spaces became narrowed and a labial-like hyperplasia appeared in the anterior margin of vertebrae.In the upright posture group,the body weight,diameter and perimeter significantly lowered than that of the normal group（P0.01）.In the upright posture group and posture recovery group,diameter and perimeter increased significantly as compared with the normal group（P0.01）.There existed pathological changes in the kidney tissues,and the size of glomerulus increased significantly（P0.01）.Conclusion The pathological changes of lumbar vertebrae due to upright posture may cause the pathological changes in the kidney tissues and the posture recovery improves these pathological changes.There is a close relationship between the lumbus and kidney.The TCM theory that the lumbus is the house of kidney is proved through the very modern experiment.
出处
《中医杂志》
CSCD
北大核心
2011年第6期511-514,共4页
Journal of Traditional Chinese Medicine
基金
上海市科技发展基金项目(08DZ1973000
09DZ1976600)
上海市科委科研平台建设专项(09DZ1974303)
关键词
腰为肾之府
直立体位
腰椎病变
lumbus being the house of the kindney
lumbus disorder
upright posture
