摘要
目的研究脑脊液（CSF）与血浆的蛋白、糖、氯化物含量不同比值鉴别诊断结核性脑膜炎（结脑）与病毒性脑膜炎（病脑）的意义。方法检测102例结脑和107例病脑患者CSF和血浆的蛋白、糖、氯化物含量,计算CSF与血浆的蛋白、糖、氯化物含量3种不同比值（CSF/血浆蛋白≥0.2、糖≤0.5、氯≤0.7,CSF/血浆蛋白≥0.1、糖≤0.6、氯≤1.1,CSF/血浆蛋白≥0.3、糖≤0.4、氯≤0.6）诊断结脑的敏感性和特异性。结果结脑组CSF与血浆的蛋白、糖、氯化物含量3种比值的阳性率均显著高于病脑组（P〈0.05~0.01）;以CSF/血浆的蛋白≥0.2、糖≤0.5、氯≤0.7诊断结脑的敏感性（96.1%,97.1%,99.0%）和特异性（97.2%,98.1%,99.1%）均较高,而CSF/血浆的蛋白≥0.1、糖≤0.6、氯≤1.1的特异性（66.4%,69.2%,75.7%）较低,CSF/血浆的蛋白≥0.3、糖≤0.4、氯≤0.6的敏感性（48.0%,44.1%,42.2%）较低。结论 CSF与血浆的蛋白、糖、氯化物含量比值≥0.2、≤0.5及≤0.7对鉴别诊断结脑与病脑具有重要意义。
Objective To investigate the significance of different ratio of cerebrospinal fluid（CSF） to plasma（P） protein（Pro）,glucose（G） and chlorides（C） in differential diagnosis tubercolous meningitis and virus meningitis.Methods The cerebrospinal fluid and plasma concentrations of Pro,G and C were measured in 102 patients with tubercolous meningitis and 107 patients with virus meningitis.The sensitivity and specificity of the 3 ratio of CSF/P Pro,G and C（CSF/P Pro≥0.2,G≤0.5,C≤0.7;CSF/P Pro≥0.1,G≤0.6,C≤1.1;CSF/P Pro≥0.3,G≤0.4,C≤0.6） in diagnosing tubercolous meningitis and virus meningitis was calculated.Results The positive rate of the 3 ratios were significantly higher in tubercolous meningitis group than those in virus meningitis group（P0.05-0.01）.As an index for diagnosing tubercolous meningitis： CSF/P Pro≥0.2,G≤0.5,C≤0.7 respectively had higher sensitivity（96.1%,97.1%,99.0%） and specificity（97.2%,98.1%,99.1%）.The CSF/P Pro≥0.1,G≤0.6,C≤1.1 had lower specificity（66.4%,69.2%,75.7% respectively）,and CSF/P Pro≥0.3,G≤0.4,C≤0.6 had lower sensitivity（48.0%,44.1%,42.2% respectively）.Conclusion The ratio of CSF/P Pro≥0.2,G≤0.5,C≤0.7 have important significance in differential diagnosis tubercolous meningitis and virus meningitis.
出处
《临床神经病学杂志》
CAS
北大核心
2011年第1期18-20,共3页
Journal of Clinical Neurology
关键词
脑脊液
血浆
蛋白
糖
氯化物
结核性脑膜炎
病毒性脑膜炎
cerebrospinal fluid
plasma
protein
glucose
chloride
tubercolous meningitis
virus meningitis
