摘要
[目的]探讨K-ras及hMSH2蛋白在年轻妇女子宫内膜癌（EC）组织中的表达及相关性.[方法]选取因子宫病变行子宫全切的标本66例,其中EC 42例、子宫内膜非典型增生6例、正常子宫内膜18例.测定其内膜组织中K-ras及hMSH2的表达.[结果]①在正常子宫内膜、子宫内膜不典型增生及EC中K-ras均呈高表达,且差异有显著性（P＜0.05） hMSH2的表达率分别为44.44%、33.33%、73.81%,差异有显著性（P＜0.05）.②K-ras及hMSH2在EC中的表达与临床分期、组织学分级、肌层浸润深度及有无淋巴转移无关（P＞0.05）.③在EC中K-ras与hMSH2表达呈正相关（rs=0.351,P＜0.05）.[结论]K-ras表达发生在EC的早期,与预后无关 hMSH2的表达与肿瘤细胞的增殖有关.
[Objective] To study the expressions and relationship between K ras and hMSH2 in endometri al carcinoma（EC） in young women under 45 years old. [Methods] Totally 66 uterine specimens which were excised for uterine diseases, including 42 cases of EC, 6 cases of atypical endometrial hyperplasia and 18 cases of normal endometrium, were selected. The expressions of K-ras and hMSH2 in the tissues of endometrium were detected. [Results] The expressions of K-ras were higher in normal endometrium, atypical endometrial hyperplasia and endometrial carcinoma, and there were significant differences among them（ P〈0.05）. The expression rates of hMSH2 were 44. 44% 33.33% and 73.81%,respectively, and there were also significant differences（ P〈0. 005）. But the expressions of K-ras and hMSH2 had no relationship with clinical stages, histological grades, myometrial invasion depth and lymphatic metastasis whether or not（ P〉0.05）. In endometrial carcinoma group, there was positive correlation between K ras and hMSH2 （rs=0. 351, P〈0.05）. [Conclusion] The expression of K-ras occurs in the early stage of endometrial carcinoma and has no relation with prognosis. The expression of hMSH2 is related with the proliferation of tumor cells.
出处
《医学临床研究》
CAS
2011年第2期293-296,共4页
Journal of Clinical Research
