摘要
[目的]研究七氟醚预处理对缺血再灌注心肌保护的线粒体相关蛋白的变化.[方法]采用双向凝胶电泳技术对七氟醚预处理（S组）与对照组（C组）大鼠心肌线粒体蛋白质进行分离和比较分析.[结果]S组与C组相比,有21个蛋白质表达发生了改变,其中表达增强的有17个蛋白,表达降低的有4个蛋白.[结论]这些差异表达的蛋白质可能参与了七氟醚预处理对心肌的保护作用.
[Objective] To explore the changes of mitochondria related proteins for myocardal protection of sevoflurane delayed preconditioning in ischemic reperfusion rats. [Methods] Two dimensional polyacrylamide gel electrophoresis（2-DE） was used to separate and compare the rat myocardium mitochondria in sevoflurane delayed preconditioning group（group S） and control group（group C）. [Results] Compared with group C, the expression of 21 proteins changed in group S, in which the expression of 17 proteins increased and the expression of 4 proteins decreased. [Conclusion] These differential expression proteins may be involved in the myo cardiai protection of sevoflurane delayed preconditioning.
出处
《医学临床研究》
CAS
2011年第2期220-223,共4页
Journal of Clinical Research
基金
湖南省自然科学基金项目（10JJ4021）
