摘要
目的:探讨氯丙米嗪合并氯丙嗪治疗强迫症的临床疗效。方法:对原用氯丙米嗪治疗为主的52例强迫症患者随机分成两组,一组加用氯丙嗪(研究组),另一组仍用氯丙米嗪(对照组),治疗8周,用Y-BOCS、HAMA评定两组精神症状变化,用t检验对照分析。结果:研究组的HAMA、Y-BOCS总分比对照组明显下降,且有显著性差异(P<0.01)。结论:强迫症患者,采用氯丙嗪合并氯丙米嗪治疗,可提高疗效。
Objective ：To observe the clinical efficacy of chlorpromazine and clomipramine in the treatment of obsessive - compulsive disorder （OCD）. Methods ：52 cases of obsessive -compulsive disorder patients, who were cured by clomipramine in the previous treatment, were divided randomly into two groups. One of them, which was called as the treatment group, were cured combined with chlorpromazine for the next 8 weeks, while the other one （the control group） were still going on treated by clomipramine only during the period. Over the duration of treatment, Y - BOCS and HAMA were used to evaluate the changes of mental symptoms of patients of these two groups. At the same time, t - test was also used to analyse them. Results： The total score of Y - BOCS and HAMA of the treatment group was decreased sharply compared with that of the control group and the differences between these two groups are significant （P 〈 0.01 ）. Conclusions： The curative effect of obsessive - compulsive disorder （OCD） will be improved by using chlorpromazinc combined with clomipramine.
出处
《中国民康医学》
2011年第5期558-559,共2页
Medical Journal of Chinese People’s Health
关键词
氯丙嗪
强迫症
氯丙米嗪
Chlorpromazine
Obsessive - compulsive disorder
Clomipramine
