摘要
由1,3-双(氨基酸丙酯盐酸盐)-5-氟尿嘧啶与膦甲(乙)酸乙酯在DMF中反应制得二十种主链含氨基酸、膦甲(乙)酸乙酯和5-氟尿嘧啶三组分的聚合物。通过核磁、红外和紫外光谱以及元素分析测定了聚合物的结构。并试验了聚合物的体外抗肿瘤活性。
Twenty new polyphosphoramides and polyphosphates were peepared from aminoacid 5--fluorouracil--1, 3--dipropylesters with (ethoxyacetyl) phosphonic dichloride or(ethoxycarbonyl) phosphonic dichloride in DMF in vacuo or in the presence of Et_3N.The polymers were structureally characterized by ~1H NMR, IR and UV as well aselemental analysis. The antitumor activity of all of the polymes were tested againstEAC in vitro. The preliminary results indicate that the polymers containing valine,serine, phenylalanine and tyrosine have better antitumor activity.
出处
《功能高分子学报》
CAS
CSCD
1989年第3期223-230,共8页
Journal of Functional Polymers
关键词
杭癌药
氟尿嘧啶
氨基酸
聚磷酰胺
Antitumor activity
5-fluorouacil
Amino acid
Polyphosphoramides
Polyphsphates
