摘要
为探讨血浆降钙素基因相关肽含量与糖尿病及其并发症之间的关系,采用放射免疫分析法测定28例正常人和67例非胰岛素依赖型糖尿病患者血浆降钙素基因相关肽水平的变化,结果显示:糖尿病无并发症患者血浆降钙素基因相关肽含量较对照组略有降低,但差异无显著意义(p>0.05);伴有并发症各组明显低于对照组(p<0.001)伴有并发症者较无并发症者也显著降低(p分别<0.05,<0.001,<0.001)。随着伴有的并发症的增多,即糖尿病病情的加重,血浆降钙素基因相关肽水平也随之降低。但降钙素基因相关肽与血糖含量无显著相关性(p>0.05)。提示,血浆降钙素基因相关肽水平的降低可能与糖尿病并发症的发展密切相关。
To discuss the clinic meanings of the levels of plasma calcitonin gene - related peptide (CGRP) in patients with diabetes mellitus (DM) . Methods: The plasma CGRP levels were measured in 67 cases with NIDDM and 28 normal subjects by radioimmunoassay. Results: It showed that the CGRP levels were slightly lower in diabetic patients without complications than those in normal subjects (p > 0. 05, nosignificance). However the plasma CGRP levels were much lower (p < 0.05, p< 0.001, p<0. 001, respectively) in diabetic patients with complications than in those without complications. The decreased CGRP levels were related to complications such as hypertention and/or angiopathy. There were no significant correlations between plasma CGRP and blood glucose levels. Conclusions: These data suggested that the changes of plasma CGRP levels might be closely related to the development of diabetic complications.
出处
《放射免疫学杂志》
CAS
1999年第4期207-209,共3页
Journal of Radioimmanology
