摘要
目的:探讨血小板反应素(TSP-1)、血管内皮生长因子(VEGF)在子宫内膜异位症(EMS)患者中全身及局部的表达情况及临床意义。方法:用ELISA和western-blotting分别对异位内膜组40例、在位内膜组40例、正常内膜组20例患者的血清及局部TSP-1、VEGF的表达进行测定比较。结果:血清中TSP-1异位内膜组明显低于在位内膜组及正常内膜组(P<0.01),在位内膜组与正常内膜组之间差异无显著性(P>0.05);VEGF的表达异位内膜组明显高于在位内膜组及正常内膜组,在位内膜组高于正常内膜组(P<0.01)。局部的表强度正常内膜组、在位内膜组、异位内膜组VEGF依次增强,TSP-1依次减弱(P<0.01)。结论:TSP-1和VEGF均参与了EMs的发生发展,VEGF的增高可能是主要因素。
Objective：To study the systemic and local expression and significance of thrombospondin-1（TSP-1）and vascular endothelial growth factor（VEGF） in endometriosis（EMS）.Methods：ELISA and Western-blotting were employed to detect TSP-1and VEGF expression in blood serum and local endometrium in 40 cases of ectopic endometrium,40 cases of eutopic endometrium and 20 cases of normal endometrium.Results：SerumTSP-1 in ectopic endometrium group was lower than that in eutopic and normal endometrium groups（P0.01）.And there was no significant difference between eutopic and normal endometrium groups（P0.05）.But VEGF in ectopic endometrium group wais higher than that in eutopic endometrium group,VEGF in eutopic endometrium group was higher than that in normalgroup（P0.01）.In local tissues,VEGF was stronger in turn in ectopic endometrium,eutopic endometrium and nomal endometrium but TSP-1 was weakened in order（P0.01）.Conclusion：Both TSP-1 and VEGF participate in the endometriosis pathogenesis.But the VEGF maybe has more important effect.
出处
《现代医药卫生》
2011年第5期664-665,共2页
Journal of Modern Medicine & Health
