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丙型肝炎疫苗研究进展 被引量：1

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摘要 丙型肝炎病毒（hepatitisCvirus，HCV）是一种黄病毒属的单股正链嗜肝RNA病毒，是引起慢性肝病的主要病原体。据估计全球约有1．7亿HCV感染者，每年约有3—4百万的新增人口约80％的新增病例发展为慢性。接近10—20％慢性感染者发展为肝硬化，并成为发生肝癌的高危人群。
作者 黄小军 吕欣
机构地区 西安第四军医大学基础部教学实验中心 第四军医大学微生物学教研室
出处 《国际病毒学杂志》 2011年第1期29-32,共4页 International Journal of Virology
基金 国家863专项课题（2007AA022441）项目资助
关键词 丙型肝炎病毒 疫苗
分类号 R512.630.1 [医药卫生—内科学]
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参考文献23

  • 1Von Hahn T, Yoon JC, Alter H,et al. Hepatitis C virus continu- ously escapes from neutralizing antibody and T-cell responses dur- ing chronic infection in vivo. Gastroenterology, 2007,132 ( 2 ) : 667-678.
  • 2Falkowska E, Kajumo F, Garcia E, et al. Hepatitis C virus enve lope glycoprotein E2 glycans modulate entry, CD81 binding, and neutralization. J. Virol,2007,81 (15) :8072-8079.
  • 3Timpe JM, Stamataki Z, Jennings A,et al. Hepatitis C virus cell cell transmission in hepatoma cells in the presence of neutralizing antibodies. Hepatology,2008,47 ( 1 ) : 17-24.
  • 4Barber DL, Wherry E J, Masopust D, et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature, 2006,439 ( 7077 ) : 682-687.
  • 5Urbani S, Amadei B, Tola D,et al. PD-1 expression in acute hep atitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. J. Virol, 2006,80 ( 22 ) : 11398 -11403.
  • 6Bowen DG, Shoukry NH, Grakoui A, et al. Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. J. Vir ol,2008,82(10) :5109-5114.
  • 7Firbas C, Boehm T, Buerger V, et al. Immunogenicity and safety of different injection routes and schedules of IC41, a Hepatitis C virus (HCV) peptide vaccine. J. Vaccine, 2010,28:2397-2407.
  • 8Firbas C, Jilma B, Tauber E, et al. Immunogenicity and safety of a novel therapeutic hepatitis C virus (HCV) peptide vaccine : a randomized, placebo controlled trial for dose optimization in 128 healthy subjects. Vaccine, 2006,24 (20) :4343-4353.
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  • 10Wedemeyer H, Schuller E, Schlaphoff V, et al. Therapeutic vaccine ICA1 as late add-on to standard treatment in patients with chronic hepatitis C. Vaccine, 2009,27(37) :5142-5151.

同被引文献15

  • 1丙型肝炎防治指南[J].临床肝胆病杂志,2004,20(4):197-203. 被引量：732
  • 2谢尧,赵辉,鸥蔚妮,闫杰,杜邵财,徐道振.不同感染途径慢性丙型肝炎患者HCV基因型分布的差异[J].中华实验和临床病毒学杂志,2004,18(3):247-250. 被引量：30
  • 3GIANNINI C, BRECHOT C. Hepatitis C virus biology[J]. Cell Death Differ, 2003, 10 (Suppl 1) .. s27 -s38.
  • 4SIMMONDS P. Genetic diversity and evolution of hepatitis C vi- rus -15 years on[J]. J Gen Virol, 2004, 85(11 ) : 3173 -3188.
  • 5CANDOTTI D, TEMPLE J, SARKODIE F, et al. Frequent recov- ery and broad genotype 2 diversity characterize hepatitis C virus infection in Ghana[J]. J Virol, 2003, 77 (14).. 7914-7923.
  • 6SIEVERT W, ALTRAIF I, RAZAVI HA, et al. A systematic re- view of hepatitis C virus epidemiology in Asia, AustraLia and Egypt[J]. Liver Int, 2011,31(Suppl 2);61 -80.
  • 7DIAS PT, HAHN JA, DELWART E, et al. Temporal changes in HCV genotype distribution in three different high risk popu- lations in San Francisco, California [J]. BMC Infect Dis, 2011 , 29(11 )..208 -209.
  • 8潘剑,俞海英,丁巧云,等.慢性丙型肝炎患者HCV基因型分析[J].实用肝脏病杂志.2005(19):75-76.
  • 9TOYODA H, KUMADA T, SHIMADA N, et al. Significance of a reduction in HCV RNA levels at 4 and 12 weeks in pa- tients infected with HCV genotype lb for the prediction of the outcome of combination therapy with peginterferon and ribavirin[J]. BMCInfect Dis, 2012, 27(12): 324 -332.
  • 10BLATT LM, MUTCHNICK MG, TONG M J, et al. Assess- ment of hepatitis C vius RNA and genotype from 6807 pa- tients with chronic hepatitis C in the United States[ J], J Vi- ral Hepat, 2000, 7(3) : 196 -202.

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国际病毒学杂志
2011年 第1期

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