摘要
检测急性重量型肝炎患者肝组织中庚型肝炎病毒（ＨＧＶ） 的存在状况及探讨与发病的关系，采用免疫组化方法以抗－ ＨＧＶＮＳ５ 单克隆抗体对２６ 例急性重型肝炎患者尸检肝组织中的ＨＧＶ 等抗原进行了检测。结果显示２６ 例肝组织中检测出ＨＧＶ 阳性６ 例（２３ ．１ ％ ） 。ＨＧＶＮＳ５Ａｇ 阳性着色颗粒表达于残存的肝细胞浆内，阳性细胞呈片簇状分布于汇管区周围。６ 例中４例重叠有ＨＢＶ 或／ 和ＨＣＶ 感染，肝组织中ＨＢｓＡｇ 或／ 和ＨＣＶ ＮＳ３Ａｇ 检测阳性，另２ 例肝组织中仅见ＨＧＶ ＮＳ５ 抗原表达。ＨＧＶ 感染可能与一些急性重型肝炎发病有关。
To investigate the existence of HGV antigen in liver tissues and the relationship between HGV infection and acute fulminant hepatitis.HGV NS5 antigen was detected by immunohistochemical method in paraffin-embedded autopsy liver tissues from patients with acute fulminant hepatitis.HGV NS5 antigen was found in 6 cases from 26 samples(23.1%).The staining signals of HGV NS5 antigen were expressed in the cytoplasm of residual hepatocytes which distributed mainly near peripotal in the form of clusters.Among 6 cases,four were found to be coinfected with HBV and /or HCV,in which HBsAg and HCV NS3 antigen were also detected out in liver tissues.The other two cases,with detective HGV NS5 antigen alone,were investigated for clinical data respectively.Our results support that HGV infection is associated with some Acute fulminant hepatitis.
出处
《临床肝胆病杂志》
CAS
北大核心
1999年第4期241-243,共3页
Journal of Clinical Hepatology
关键词
庚型肝炎病毒
免疫组化
庚型肝炎
检测
Hepatitis G virus Immunohistochemistry Acute fulminant hepatitis
