摘要
为寻求一种治疗慢性乙型肝炎的新方法，应用ＨＢＶ 特异性Ｔ 细胞输注治疗慢性乙型肝炎９ 例。结果显示，在疗程结束后，患者的ＨＢｓＡｇ、ＨＢｅＡｇ、ＨＢＶＤＮＡ 的含量均有所下降。其中ＨＢｅＡｇ 下降较明显，Ｐ＜ ０－０１ 。２ 例ＨＢｃＡｇ 阳性患者，ＨＢｃＡｇ 阴转。ＣＤ３＋ 、ＣＤ４＋ 、ＣＤ４ ＋ ／ＣＤ８ ＋ 、ＮＫ活性上升，ＣＤ８＋ 、ｓＩＬ－ ２Ｒ 较治疗前有所回复。表明特异性Ｔ 细胞治疗慢性乙型肝炎有一定疗效，远期疗效在观察中。
In order to seek a new method for treating chronic hepatitis B,9 cases of chronic hepatitis B were treated by transfusing hepatitis B virus antigen specific T cclls.The results showed that after the treatment level of HBsAg、HBeAg and HBV DNA in sera of patients with chronic hepatitis B decreased in some degree,and level of HBe Ag in sera decreased more remarkably than that of HBsAg and HBV DNA,(P<0 01)HBcAg of 2 cases changed from positive to negative.Frequencies of CD 3 +、CD 4 +、CD 4 +/CD 8 + T cells and NK cells in sera were increased mean while frequency of CD 8 + T cells and sIL-2R level in sera were decreased to normal levels.The results suggest that transfusion of hepatitis B virus antigen specific T cells have effects in some extent for treating chronic hepatitis B.
出处
《临床肝胆病杂志》
CAS
北大核心
1999年第4期230-231,229,共3页
Journal of Clinical Hepatology
