摘要
目的:比较欣母沛和巧特欣预防和治疗宫缩乏力所致产后出血的效果。方法:选择在上海市嘉定区妇幼保健院阴道分娩的产妇及剖宫产产妇190例,随机分成两组。欣母沛组91例单次使用欣母沛250μg,宫体或臀部肌肉注射。巧特欣组99例使用巧特欣100μg静脉推注。观察术后2 h内出血量、子宫张力的改变情况、产后2 h内需要的额外干预措施、用药前后的血压变化及用药后的不良反应等,并进行成本效果分析。结果:巧特欣组与欣母沛组在产后2 h内出血量及子宫张力改变方面均无统计学差异,两组产后2 h内需要额外干预的情况均较少,两组用药前后血压变化、药物不良反应等方面亦无统计学差异,但欣母沛的成本效果比较巧特欣高。结论:欣母沛与巧特欣预防产后出血效果均较好,但巧特欣更经济实用。
Objective：To compare the effects of Hemabate and Carbetocin in prevention and treatment of postpartum hemorrhage induced by uterine inertia.Methods：190 pregnant women adopting vaginal delivery and cesarean section in the hospital were divided into two groups randomly： 91 pregnant women in Hemabate group were treated with 250 μg Hemabate（injected into uterus body or intramuscular injection）;99 pregnant women in Carbetocin group were treated with intravenous injection of 100 μg Carbetocin;the amount of blood loss at 2 hours after operation,changes of uterine tension,excess intervention measures needed at 2 hours after operation,changes of blood pressure and adverse reactions after treatment were observed,cost-effectiveness analysis was carried out.Results：There was no significant difference in the amount of blood loss at 2 hours after operation and changes of uterine tension between Hemabate group and Carbetocin group,the excess intervention measures needed at 2 hours after operation were few,there was no significant difference in changes of blood pressure and adverse reactions after treatment between Hemabate group and Carbetocin group;the cost-effectiveness of Hemabate was higher than that of Carbetocin.Conclusion：Carbetocin combined with Hemabate are effective in prevention of postpartum hemorrhage,but Carbetocin is more economical.
出处
《中国妇幼保健》
CAS
北大核心
2011年第5期764-766,共3页
Maternal and Child Health Care of China
关键词
欣母沛
巧特欣
产后出血
Hemabate
Carbetocin
Postpartum hemorrhage
