摘要
目的:观察男性非小细胞肺癌患者血清雌二醇、睾酮水平及补肺消积方的调控作用。方法:用随机数字表法将48例男性非小细胞肺癌患者分成治疗组及对照组各24例。治疗组:补肺消积方+NP或CP方案静脉化疗2周期。对照组:单用NP或GP方案(用法剂量同治疗组)静脉化疗2个周期。分别于化疗前1天、第2个周期结束后(即第56天)按化学发光免疫法监测血清雌二醇、睾酮。结果:治疗组血清雌二醇从82.5pg/ml±9.7pg/ml下调至73.2pg/ml±10.1pg/ml,差异有统计学意义(P<0.05);有效率治疗组36.4%,对照组为26.1%,两组差异无统计学意义(P>0.05);治疗组出现Ⅲ度～Ⅳ度白细胞减少的患者占13.6%,相比对照组(43.6%)明显减少(P<0.05);治疗组有68.2%的患者Karnofsky评分改善,相比对照组(34.8%)明显提高,差异有统计学意义(P<0.05)。结论:补肺消积方可下调非小细胞肺癌患者血清雌二醇水平,有一定的调节内分泌作用;可降低化疗所致的Ⅲ度～Ⅳ度白细胞减少的发生率。
Objective： To investigate the sexual hormones levels in blood serum of male patients with NSCLC and the regulation effects of Bufeixiaoji Decoction. Methods： 48 cases of NSCLC were randomized into treatment group（24 cases） and control group （24 cases）. Patients in treatment group were treated by Bufeixiaoji Decoction and chemotherapy with NP or GP regimen for two cycles. Patients in control group were treated by chemotherapy with NP or GP regimen for two cycles. 28 days were as one cycle . Blood serum of every case was collected one day before chemotherapy and d56 respectively. Results： The serum estradiol levels were significantly decreased in treatment group after therapy （ P 〈 0. 05 ）. There was no significant difference of effective rate between treatment group （36. 4% ） and control group（26. 1% ） （P 〉0. 05）. 13.6% of the patients in treatment group got Ⅲ to Ⅳ degree leucopenia which was significantly less than that in control group （43.6%） （P 〈 0. 05）. Karuofsky scores improved significantly in 68. 2% of patients in treatment group comparing with that of the control group （34. 8% ） （P 〈 0. 05 ）. Conclusion： The estradiol levels in blood serum of patients with NSCLC would be one of the prognostic signs and Bufeixiaoji Decoction can regulate the imbalance of sexual hormone metabolism in male with NSCLC.
出处
《肿瘤预防与治疗》
2011年第2期103-106,共4页
Journal of Cancer Control And Treatment
关键词
非小细胞肺癌
补肺消积方
雌二醇
睾酮
Non-small Cell Lung Cancer
Bufeixiaoji Decoction
Estradiol
Testosterone
