摘要
目的 观察顺铂＋５氟尿嘧啶（ＤＤＰ＋ ５Ｆｕ） 方案治疗食管癌的疗效。方法 中晚期食管癌１５６ 例，其中２４ 例除原发灶外另有远处转移。初治１４０ 例，复治１６ 例。以ＤＤＰ周期剂量不同分为Ａ、Ｂ两组，两组５Ｆｕ 用量、用法相同。Ａ组ＤＤＰ７５～１００ ｍｇｍ２ ，Ｂ组ＤＤＰ５０ ～７４ ｍｇｍ２ 。结果 原发灶肿瘤完全缓解２６ 例，部分缓解７１ 例，病情稳定４０ 例，进展１９ 例，总有效率６２．２％ （９７１５６） ；转移癌有效率３７．５％ （９２４） ，明显低于前者（ Ｐ＜ ０．０５）。初治者有效率为６５ ．７％ ，明显高于复治者的３１．３ ％（ Ｐ＜０ ．００１） 。Ａ、Ｂ两组有效率分别为７０．８ ％ 和５６．０ ％ ，差异无显著性。两组化疗有效者的中位缓解期４ ．５ 个月，中位生存期８ ．２ 个月，１ 年、２ 年生存率分别为１５ ．２％ 和５．２％ 。主要毒性为消化道反应、骨髓抑制和静脉炎。结论 ＤＤＰ＋５Ｆｕ 对食管癌有较好的疗效且毒性不大。
Objective To evaluate the results of combination chemotherapy with cisplatin (DDP) plus 5 fluorouracil(5 FU) in the treatment of advanced esophageal cancer.Methods From 1988 through 1997, 156 patients with advanced esophageal cancer were enrolled in this study. The median age of the patients was 60. Squamous cell cancer was the most common type of malignancy. All but 16 patients received no previous chemotherapy. Results Complete response was observed in 26 patients and partial response in 71 patients, with an overall response rate of 62.2%. The response appeared to correlate with dose intensity, as 65.7% response rate was achieved with a dose of DDP 75～100 mg/m 2 versus 43.7% response rate with DDP 50～70 mg/m 2. The median response duration was 4.5 months and the median survival period was 8.2 months. Nausea/vomiting, neutropenia and phlebitis were the main adverse reactions in all treated cases. Conclusion A high response rate was obtained in advanced esophageal cancer treated by DDP plus 5 FU with tolerable toxicity.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1999年第5期389-391,共3页
Chinese Journal of Oncology
关键词
食管肿瘤
药物疗法
顺铂
5-氟尿嘧啶
Esophageal neoplasms/drugtherapy Cisplatin/therapeutic use 5 fluorouracil/therapeutic use
