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BRAFV600E突变与甲状腺乳头状癌诊治研究进展 被引量：2

Progress in the BRAFV600E mutation and papillary thyroid carcinoma
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摘要 BRAFV600E突变是甲状腺乳头状癌中最常见的基因突变，在甲状腺乳头状癌的发生发展和浸润转移中发挥了重要作用。BRAFV600E突变对甲状腺乳头状癌的诊断和预后判断有重要的价值，针对BRAF蛋白激酶及其下游效应器的靶向抑制剂治疗是BRAFV600E突变甲状腺癌治疗的新方向。 BRAFV600E mutation is the most common genetic alteration in the papillary thyroid carcinoma. It plays an important role in the tumorigenesis, invasiveness and metastasis of the papillary thyroid carcino- ma. Testing of BRAFV600E mutation is of great value in diagnosis, which also can be used as a prognostic maker of papillary thyroid cancer. Inhibitors treatment targeted to BRAF kinase and its downstream effectors is a new area in the treatment of BRAFV600E Emutated thyroid cancer.
作者 苏艳军 刁畅 张建明 程若川
机构地区 昆明医学院第一附属医院胃肠与甲状腺外科
出处 《国际外科学杂志》 2011年第2期104-109,共6页 International Journal of Surgery
关键词 BRAF突变 甲状腺乳头状癌 诊断 治疗学 BRAF mutation Papillary thyroid carcinoma Diagnosis Therapeutics
分类号 R736.1 [医药卫生—肿瘤]
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参考文献42

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同被引文献20

  • 1黄艳明,赖祥进.蛋白质组学及其在甲状腺肿瘤研究中的应用[J].实用癌症杂志,2006,21(1):101-103. 被引量：1
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国际外科学杂志
2011年 第2期

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