摘要
目的:分析胱抑素C(Cys-C)、血肌酐(SCr)、血红蛋白(Hb)在肾功能变化过程的改变情况。方法:回顾性分析201例行肾动态显像患者,记录同时期患者Cys-C、SCr、Hb的水平,并将两者与肾动态显像计算所得GFR_总做相关分析。同时以GFR_总为肾功能改变的分级标准,将201例患者分成5组,观察Cys-C、SCr、Hb水平在肾功能各个阶段的变化情况。结果:在肾功能改变的不同阶段,Cys-C、SCr之间的差别具有显著性(P<0.05);Hb仅在肾功能轻度、中度受损两组间差别不具有显著性(P>0.05)。Cys-C、SCr分别与GFR_总存在明显相关,前者相关程度更高。Hb与GFR_总相关较弱。当60min/ml≤GFR总<80min/ml时,Cys-C较SCr更为敏感,两者之间的差别具有显著性x^2=17.168,P<0.01。Hb降低比例随着肾功能损伤加重而升高,且贫血程度加重。结论:Cys-C较SCr能够更好地反映肾功能的改变,特别在肾功能受损早期更为敏感。随着肾功能损伤的进展,患者贫血程度加重。
Objective To study the changes of blood cystatin C （ Cys C）, creatinine and hemogloblin levels in patients with different levels of GFR. Methods GFR levels were examined with renal dynamic imaging （ with 99mTc-DTPA） in 201 patients with various kinds of chronic renal diseases. Blood Cys C, creatinine and hemoglobin levels were determined with biochemistry in these patients. The patients were divided into 5 groups according to their GFR levels： Group A, GFR~〉80min/ml （renal function normal, n = 21 ）, Group B, 60ml/min ~〈 GFR 〈 80ml/min （ mild impairment, ,t = 39 ）, Group C, 30ml/min 〈 GFR 〈 60ml/min （ moderate im- pairment, n = 50）, Group D 15ml/min ≤ GFR 〈 30ml/min （ advanced impairment, n = 37 ） and Group E GFR 〈 15ml/min （ end stage, n = 54）. Results The blood levels of of Cys C and creatinine among different groups of patients were all significantly different （ P 〉 0.05 ）. Anemia with significant decrease of hemoglobin levels developed in Group D and Group E patiems. Blood levels of both Cys C and ereatinine were significandy negatively correlated with GFR levels. However, in patients with mild renal function impair- ment, Cys C was a more sensitive indicator. In dais study, among the 39 Group B patients, Cys C levels were increased in 32 cases （82.1%）, but ereatinine levels were increased in 14 cases （35. 9%） only： the difference was significantly （X2 = 17. 168, P 〈 0.01 ）. Conclusion Changes of blood Cys C levels could reflect renal function impairment better than changes of blood ereatinine level did, especially at the initial stage. Anemia developed later in the course of chronic renal failure.
出处
《放射免疫学杂志》
CAS
2011年第1期6-8,共3页
Journal of Radioimmanology
