摘要
目的观察醛固酮受体拮抗剂(安体舒通)治疗扩张型心肌病(DCM)的临床疗效。方法将83例DCM心力衰竭患者随机分为对照组和治疗组,对照组给予基础用药,治疗组给予基础用药+安体舒通。6个月后复查心脏超声指标和血清心肌纤维化指标。结果治疗后两组心脏超声指标均改善,心肌纤维化指标下降,且两组比较差异有统计学意义(P<0.05)。结论安体舒通能明显改善DCM患者心功能及逆转心肌纤维化。
Objective To evaluate the therapeutic efficacy of antisterone on patients with dilated cardiomyopathy.Methods Eighty-three patients with dilated cardiomyopathy were randomly divided into control group（42 cases） and treatment group（41 cases）.Routine general therapy was given to the control group,the patients in treatment group took antisterone 20 mg per day besides routine general therapy.The echocardiography was perfomed and myocardial fibrosis level（PCⅢ,HA,LN） was tested before and after 6 months of the treatment.Results Six months after treatment,LV,RV diminished,LVESV,LVEDV decreased and LVEF increased in the two groups;the PCⅢ,HA,LN levels were reduced in the two groups;but improved more significantly in the treatment group than that in the control group（P0.05）.Conclusion Spironolatone can improve cardiac function and the myocardial fibrosis level of dilated cardiomyopathy.
出处
《临床医学》
CAS
2011年第2期13-14,共2页
Clinical Medicine
关键词
醛固酮受体拮抗剂
扩张型心肌病
Aldosterone receptor antagonist
Dilated cardiomyopathy
