摘要
目的 探讨阻断乙型肝炎病毒（HBV）垂直传播的有效方案.方法 将387对夫妇（其必有一方HBV-DNA阳性）按要求分三组后再随机分组,用拉米夫定、乙肝免疫球蛋白（HBIG）干预.其HBV-DNA阳性婴儿共90例随机分三组,用HBIG、重组粒细胞-巨噬细胞集落刺激因子（Gm-CSF）、乙肝疫苗干预,用荧光探针定量聚合酶链反应（PCR）技术动态监测父、母、婴儿血HBV-DNA定量.结果 HBV-DNA阳性父/母用药后,各组HVB-DNA水平均较用药前明显下降,联合用药组与单独用药组比较,HBV-DNA水平下降幅度有统计学意义（P＜0.05）,单独用药组与联合用药组比较,其所生婴儿HBV-DNA阳性率明显增高（P＜0.05）;HBV-DNA阳性婴儿用药后,HBV-DNA下降水平,联合用药组与疫苗组差异有统计学意义（P＜0.05）;GM-CSF＋疫苗组与HBIG＋疫苗组比较HBV-DNA水平下降幅度差异有统计学意义（P＜0.05）.结论 HBV阳性父、母孕前用HBIG、拉米夫定,婴儿用乙肝疫苗、HBIG、Gm-CSF可有效阻断HBV垂直传播.
Objective To study the way of blocking the father-child、mother-child transmission of HBV.Methods 387 fathers or mothers who were positive for HBV-DNA were divided into three groups according to the father and mother＇s HBV-DNA and anti-HBsAg. Then they were randomly divided into three groups,one group were treated by HBIG,the second group were treated by lamivudine,the third group were treated by HBIG and Lamivudine.90 of their children who were positive for HBV-DNA were randimly dinded into three groups,one group were treated by hepatitis B Vaccine,the second group were treated by hepatitis B Vaccine and HBIG,the third group were treated by hepatitis B Vaccine and Gm-CSF. Their serum HBV-DNA were tested by fluorescence quantitative - PCR method.Results After treatment on the fathers or mothers,the degree of HBV-DNA was decreased obviously. There were significant difference between the groups who were treated by HBIG and lamivudine and the group who were treated only by HBIG or lamivudine（ P 〈0.05 ）. The rate of their newborn with HBV-DNA（ ＋ ） were significantly lower then other groups. After treatment on the newborn with HBV-DNA（ ＋ ）. The degree of HBV-DNA had significant difference between the groups who were treated by both drug and vaccine and the vaccine group（P 〈0.05）. Conclusion The fathers or mothers with HBV-DNA（ ＋ ） were treated by HBIG、lamivudine before they want a child, and fheir newborn with HBV-DNA（ ＋ ） were treated by vaccine、HBIG、Gm-CSF. This was an important way to block the father-child、mother-child transmission of Hepatitis B Virus.
出处
《中国基层医药》
CAS
2011年第1期32-34,共3页
Chinese Journal of Primary Medicine and Pharmacy
