摘要
目的 研究降脂排卵方在多囊卵巢综合征治疗过程中对配体激活的核受体超家族转录因子（PPARα）、过氧化物酶体增殖物激活受体γ辅助活化因子（PGC-1α）及含有＂碱性螺旋-环-螺旋-亮氨酸拉链＂结构的核转录因子（SREBP-1c）、固醇调节元件结合蛋白裂解激活蛋白（SCAP）的调控作用.方法 选择多囊卵巢综合征患者84例随机分为中药治疗组、西药治疗组、中西医结合治疗组,中药治疗组采用降脂排卵方治疗,西药治疗组服用炔雌醇环丙孕酮片3个周期,中西医结合治疗组则同时采用中药治疗组和西药治疗组方法联合治疗.观察各组治疗前后脂质代谢相关因子的变化.结果 中西医结合治疗组可以显著提高PPARα、PGC-1α及降低SREBP-1c、SCAP拷贝数,可以显著降低体质量指数,中药组次之,而西药组则对脂质代谢相关因子及体质量指数的调控作用不明显.三组月经改善总有效率分别为71.42%、75.00%、92.86%.结论 降脂排卵方对多囊卵巢综合征患者脂质代谢相关因子PPARα、PGC-1α及SREBP-1c、SCAP有明显调控作用.
Objective To explore the effect of Jiangzhipailuan decoction in regulating PPARα（ belong to the nuclear receptor family of ligand-activated transcription factors ）, PGC- 1α （ peroxime proliferator activated releptour）and SREBP-1c（ belong to the baichelix-loop-helix-leucine zipper class of transcription factors）, SCAP（ SREBP cleavage activating protein） related to lipid metabolism in the treatment of polycystic ovarian syndrome. Methods 84 patients suffered polycystic ovary syndrome were randomly divided into 4 groups： one received traditional Chinese medicine treatment, one western medicine treatment, one combination therapy and one as the control group. Traditional Chinese medicine group was treated with Jiangzhipailuan decoction treatment for 3 months, western medicine group was treated with up to Diane-35 （ ethinyl cyproterone tablets） for three cycles, while the combination therapy group was treated with traditional Chinese medicine ,western medicine as well as combined treatment for 3 courses. Results In the combination therapy group the PPARα, PGC-1α and decreased SREBP-1c, SCAP copy number was significantly improved ,and body mass index was significantly lowered. The total improvement rate of menstrual in three groups were 71.42% ,75.00% ,92.86% respectively. Conclusion Jiangzhipailuan decoction played a prominent role in regulating PPARα,PGC-1α and SREBP-1c,SCAP related to lipid metabolism in the treatment of polycystic ovarian syndrome.
出处
《中国基层医药》
CAS
2011年第1期18-20,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
降脂排卵方
多囊卵巢综合征
脂质代谢相关因子
调控
Lipid-lowering ovulation Decoction
Polycystic ovarian syndrome
Lipid metabolism related factors
Regulation
