摘要
目的评价还原型谷胱甘肽对奥沙利铂(OXA)引起的慢性神经毒性的预防作用。方法采用随机、对照的方法,将接受FOLFOX4方案辅助化疗的105例肿瘤患者随机分为治疗组和对照组,在化疗的同时分别给予还原型谷胱甘肽(54例)和生理盐水(51例),观察两组慢性神经毒性的发生率及严重程度。结果化疗2个周期时,两组的慢性神经毒性发生率分别是37.1%和41.1%,差异无统计学意义(P>0.05);化疗4个周期时,两组的慢性神经毒性发生率分别是58.5%和66.7%,差异无统计学意义(P>0.05);化疗6个周期时,两组的慢性神经毒性发生率分别是74.0%和89.7%,差异具有显著性统计学意义(P<0.05)。结论还原型谷胱甘肽是一种有效的预防奥沙利铂引起的慢性神经毒性的治疗措施,值得临床进一步推广应用。
Objective To assess the efficacy of reduced glutathion for preventing the chronic neurotoxicity induced by oxaliplatin.Methods This is a randomized and placebo controlled clinical trail.The patients receiving FOLFOX4 chemotherapy for their solid tumor were randomized to receive reduced glutathion or normal saline with chemotherapy simultaneously.The incidence and severity of oxaliplatin-induced chronic neurotoxicity were observed.Results One hundred and five patients admitted in our department from January 2008 to March 2010 were entered into this study,including 54 patients in the trial group and 51 patients in the control group.After 2 cycles,the incidences of chronic neurotoxicity were 37.1% and 41.1%, respectively.After 4 cycles,the incidences of chronic neurotoxicity were 58.5% and 66.7%, respectively. After 6 cycles,the incidences of chronic neurotoxicity were 74.0% and 89.7%.The difference was significant between the two groups（P0.05）.Conclusion Reduced glutathion is effective in preventing chronic neurotoxicity of oxaliplatin.
出处
《中国实用医药》
2011年第2期5-6,共2页
China Practical Medicine
