摘要
目的观察依那普利与氯沙坦联用治疗高血压并发2型糖尿病患者微量白蛋白尿的临床疗效。方法将60例高血压并发2型糖尿病伴微量白蛋白尿的患者随机分为两组,分别使用氯沙坦、依那普利两药联用为治疗组(n=30),单用依那普利为观察组(n=30),疗程16周。观察两组治疗前后各组患者的血压,治疗前后尿白蛋白排泄率(UAER)。结果两组血压均较治疗前明显降低(P<0.05),但治疗后两组血压间比较,差异无统计学意义(P>005);两组患者经治疗16周后平均UAER水平分别由(108±30)μg/min、(114±31)μg/min降至(74±28)μg/min、(92±26)μg/min(均P<0.01),治疗组降低程度更为显著(P<0.05)。结论氯沙坦联合依那普利治疗在有效降压的同时,能改善高血压并发2型糖尿病患者早期肾损害,提示有早期肾损害患者应尽早联合降压治疗。
Objective To observe the therapeutic effect on hypertension patients with type 2 diabetes mellitus andmicroalbuminuria（MAU）by using Enalapril combined Valsartan.Methods Totally 60 hypertension with diabetic patients and microalbum were randomly divided into tow groups and were treated respectively with EnalaprilV combined alsartan（group A n=32）or Enalapril（group B n=28）for 16 weeks, the changes in blood pressure and MAU were determined before and after treatment. Results After treatment, UAER decreased significantly in both group A from（108 ±30）μg/min to（74 ±28）μg/min,（P0.005）, and group B from（114 ±31）μg/min to（92 ±26）μg/min,（P0. 01）but the decrease in group A was more significantly than that in group B. Conclusion Using Enalapril combined Valsartan is more effective in improving early renal damage of hypertension patients with type 2 diabetes mellitus and than using only Valsartan.
出处
《中国实用医药》
2011年第2期3-4,共2页
China Practical Medicine
关键词
高血压
糖尿病
尿微量白蛋白
依那普利
氯沙坦
Hypertension
Type 2 diabetes mellitus
Microalbuminuria
Enalapril
Valsartan
